PDB
8ZWF
Resolution
3.0 Å
Released
May 14, 2025
Receptor
C3a
Class
A
Species
Homo sapiens
Ligand
JR14a
Function
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
JR14a L30 1.39x39 TM1 hydrophobic
JR14a L82 2.64x64 TM2 hydrophobic
JR14a I98 3.28x28 TM3 hydrophobic
JR14a I102 3.32x32 TM3 hydrophobic
JR14a Y174 45.52x52 ECL2 hydrophobic
JR14a Y501 6.51x51 TM6 polar (hydrogen bond)
JR14a Y501 6.51x51 TM6 polar (hydrogen bond with backbone)
JR14a Y501 6.51x51 TM6 Van der Waals
JR14a F504 6.54x54 TM6 Van der Waals
JR14a G505 6.55x55 TM6 polar (hydrogen bond with backbone)
JR14a G505 6.55x55 TM6 Van der Waals
JR14a D525 7.35x34 TM7 polar (charge-assisted hydrogen bond)
JR14a H526 7.36x35 TM7 Van der Waals
JR14a I529 7.39x38 TM7 Van der Waals
JR14a I529 7.39x38 TM7 hydrophobic

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ICL1 M Q R ICL1ECL1 G Q W P Y ECL1ICL2 P I W C Q N H R ICL2ECL2 E I F T T D N H N R C G Y K F G L S S S L D Y P D F Y G D P L E N R S L E N I V Q P P G E M N D R L D P S S F Q T N D H P W T V P T V F Q P Q T F Q R P S A D S L P R G S A R L T S Q N L Y S N V F K P A D V V S P K I P S G F P I E D H E T S P L D N S D A F L S T H L K L F P S A S S N S F Y E S E L P Q G F Q D Y Y N L G Q F T D D D Q ECL2ICL3 G R F A K S Q ICL3ECL3 D P E ECL3N-term M A S F S A E T N S T D L L S Q P W N N-termC-term S I Q G I L E A A F S E E L T R S T H C P S N N V I S E R N S T T V C-term E P P V I L S M V I L S L T F L L G L P G N G L V L W V A G L K T V N T I W F L H L T L A D L L C C L S L P F S L A H L A L Q G R F L C K L I P S I I V L N M F A S V F L L T A I S L D R C L V V F K N V G M A C S I C G C I W V V A F V M C I P V F V Y R V P T P L V A I T I T R L V V G F L L P S V I M I A C Y S F I V F R M Q R S K T F R V A V V V V A V F L V C W T P Y H I F G V L S L L T T P L G K T L M S W D H V C I A L A S A N S C F N P F L Y A L L G K D A R Q F R K K
Helix box plot — Download: PNG | SVG G N G P L G L L F T L S L I V M S L I V 1 L H L T L A D L L C C L S L P F S L A H 2 A T L L F V S A F M N L V I I S P I L K 3 A C S I C G C I W V V A F V M C I P V 4 Y C A I M I V S P L L F G V V L R T I T I 5 V V V V A V F L V C W T P Y H I F G V L 6 F P N F C S N A S A L A I C V H D W S 7

GPCRdb(A)
GPCRdb(A)
C3a receptor
TM1
1x39 1.39x39 L30
TM2
2x64 2.64x64 L82
TM3
3x28 3.28x28 I98
3x32 3.32x32 I102
ECL2
45x52 45.52x52 Y174
TM6
6x51 6.51x51 Y393
6x54 6.54x54 F396
6x55 6.55x55 G397
TM7
7x34 7.35x34 D417
7x35 7.36x35 H418
7x38 7.39x38 I421