PDB
9AS4
Resolution
3.1 Å
Released
April 2, 2025
Receptor
5-HT2A
Class
A
Species
Homo sapiens
Ligand
(+)-LSD
Function
Agonist
Reference
10.1038/S41467-025-57956-7

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Ligand Amino Acid Generic Number Segment Interaction Type
(+)-LSD W151 3.28x28 TM3 hydrophobic
(+)-LSD D155 3.32x32 TM3 polar (charge-assisted hydrogen bond)
(+)-LSD V156 3.33x33 TM3 hydrophobic
(+)-LSD V156 3.33x33 TM3 Van der Waals
(+)-LSD S159 3.36x36 TM3 Van der Waals
(+)-LSD T160 3.37x37 TM3 Van der Waals
(+)-LSD L229 45.52x52 ECL2 hydrophobic
(+)-LSD S242 5.46x461 TM5 polar (hydrogen bond)
(+)-LSD S242 5.46x461 TM5 Van der Waals
(+)-LSD F339 6.51x51 TM6 Van der Waals
(+)-LSD F339 6.51x51 TM6 hydrophobic
(+)-LSD F340 6.52x52 TM6 aromatic (edge-to-face)
(+)-LSD F340 6.52x52 TM6 Van der Waals
(+)-LSD Y370 7.43x42 TM7 Van der Waals

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ICL1 K K L Q ICL1ECL1 Y R W P L ECL1ICL2 P I H H S R F N ICL2ECL2 D S K V F K E G S C L L A ECL2ICL3 G T R A K L A S F S F L P Q S S L S S E K L F Q R S I H R E P G S Y T G R R T ICL3ECL3 K E S C ECL3N-term M D I L C E E N T S L S S T T N S L M Q L N D D T R L Y S N D F N S G E A N T S D A F N W T V D S E N R T N L S C E G C L S P S C L S L N-termC-term Q Y K E N K K P L Q L I L V N T I P A L A Y K S S Q L Q M G Q K K N S K Q D A K T T D N D C S M V A L G K Q H S E E A S K D N S D G V N E K V S C V C-term L H L Q E K N W S A L L T A V V I I L T I A G N I L V I M A V S L E N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q K E A T L C V S D L M Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T F S R Y R S A Y I Q C
Helix box plot — Download: PNG | SVG I N G A I T L I I V V A T L L A S W N K 1 M S L A I A D M L L G L F V M P V S M L T 2 A C L H M I S A T S F L V D L Y I W V A 3 A F L K I I A V W T I S V G I S M P I 4 Y T I V M I T L P I F F S V F S G I L V F 5 G I V F F L F V V M W C P F F I T N I M 6 L P N V A S S L Y G I W V F V N L L A 7

GPCRdb(A)
GPCRdb(A)
5-HT2A receptor
TM3
3x28 3.28x28 W151
3x32 3.32x32 D155
3x33 3.33x33 V156
3x36 3.36x36 S159
3x37 3.37x37 T160
ECL2
45x52 45.52x52 L229
TM5
5x461 5.46x461 S242
TM6
6x51 6.51x51 F339
6x52 6.52x52 F340
TM7
7x42 7.43x42 Y370