PDB
9ASA
Resolution
3.1 Å
Released
April 2, 2025
Receptor
5-HT2A
Class
A
Species
Homo sapiens
Ligand
RS130-180
Function
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
RS130-180 L123 2.53x53 TM2 hydrophobic
RS130-180 D155 3.32x32 TM3 polar (charge-assisted hydrogen bond)
RS130-180 V156 3.33x33 TM3 Van der Waals
RS130-180 V156 3.33x33 TM3 hydrophobic
RS130-180 S159 3.36x36 TM3 Van der Waals
RS130-180 G238 5.42x43 TM5 Van der Waals
RS130-180 S239 5.43x44 TM5 Van der Waals
RS130-180 S242 5.46x461 TM5 Van der Waals
RS130-180 W336 6.48x48 TM6 hydrophobic
RS130-180 W336 6.48x48 TM6 Van der Waals
RS130-180 F339 6.51x51 TM6 Van der Waals
RS130-180 F339 6.51x51 TM6 aromatic (face-to-edge)
RS130-180 F340 6.52x52 TM6 hydrophobic
RS130-180 F340 6.52x52 TM6 Van der Waals
RS130-180 G369 7.42x41 TM7 polar (hydrogen bond with backbone)
RS130-180 G369 7.42x41 TM7 Van der Waals
RS130-180 Y370 7.43x42 TM7 polar (hydrogen bond with backbone)
RS130-180 Y370 7.43x42 TM7 Van der Waals

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ICL1 K K L Q ICL1ECL1 Y R W P L ECL1ICL2 P I H H S R F N ICL2ECL2 D S K V F K E G S C L L A ECL2ICL3 G T R A K L A S F S F L P Q S S L S S E K L F Q R S I H R E P G S Y T G R R T ICL3ECL3 K E S C ECL3N-term M D I L C E E N T S L S S T T N S L M Q L N D D T R L Y S N D F N S G E A N T S D A F N W T V D S E N R T N L S C E G C L S P S C L S L N-termC-term Q Y K E N K K P L Q L I L V N T I P A L A Y K S S Q L Q M G Q K K N S K Q D A K T T D N D C S M V A L G K Q H S E E A S K D N S D G V N E K V S C V C-term L H L Q E K N W S A L L T A V V I I L T I A G N I L V I M A V S L E N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q K E A T L C V S D L M Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T F S R Y R S A Y I Q C
Helix box plot — Download: PNG | SVG I N G A I T L I I V V A T L L A S W N K 1 M S L A I A D M L L G L F V M P V S M L T 2 A C L H M I S A T S F L V D L Y I W V A 3 A F L K I I A V W T I S V G I S M P I 4 Y T I V M I T L P I F F S V F S G I L V F 5 G I V F F L F V V M W C P F F I T N I M 6 L P N V A S S L Y G I W V F V N L L A 7

GPCRdb(A)
GPCRdb(A)
5-HT2A receptor
TM2
2x53 2.53x53 L123
TM3
3x32 3.32x32 D155
3x33 3.33x33 V156
3x36 3.36x36 S159
TM5
5x43 5.42x43 G238
5x44 5.43x44 S239
5x461 5.46x461 S242
TM6
6x48 6.48x48 W336
6x51 6.51x51 F339
6x52 6.52x52 F340
TM7
7x41 7.42x41 G369
7x42 7.43x42 Y370