PDB
9B54
Resolution
2.9 Å
Released
March 5, 2025
Receptor
CB1
Class
A
Species
Homo sapiens
Ligand
VIP36
Function
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
VIP36 F177 ECL1 hydrophobic
VIP36 K192 3.28x28 TM3 polar (hydrogen bond with backbone)
VIP36 K192 3.28x28 TM3 polar (charge-assisted hydrogen bond)
VIP36 L193 3.29x29 TM3 polar (hydrogen bond with backbone)
VIP36 L193 3.29x29 TM3 Van der Waals
VIP36 V196 3.32x32 TM3 Van der Waals
VIP36 V196 3.32x32 TM3 hydrophobic
VIP36 T197 3.33x33 TM3 polar (hydrogen bond)
VIP36 F200 3.36x36 TM3 hydrophobic
VIP36 F200 3.36x36 TM3 Van der Waals
VIP36 F268 ECL2 aromatic (face-to-edge)
VIP36 F268 ECL2 Van der Waals
VIP36 Y275 5.39x39 TM5 Van der Waals
VIP36 Y275 5.39x39 TM5 hydrophobic
VIP36 L276 5.40x40 TM5 Van der Waals
VIP36 W279 5.43x43 TM5 hydrophobic
VIP36 W279 5.43x43 TM5 Van der Waals
VIP36 C355 6.47x47 TM6 Van der Waals
VIP36 W356 6.48x48 TM6 hydrophobic
VIP36 W356 6.48x48 TM6 Van der Waals
VIP36 L359 6.51x51 TM6 hydrophobic
VIP36 L359 6.51x51 TM6 Van der Waals
VIP36 L360 6.52x52 TM6 Van der Waals
VIP36 M363 6.55x55 TM6 polar (hydrogen bond)
VIP36 S383 7.39x38 TM7 polar (hydrogen bond)
VIP36 C386 7.42x41 TM7 polar (hydrogen bond)
VIP36 N389 7.45x45 TM7 polar (hydrogen bond)

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ICL1 R S L R C ICL1ECL1 F H R K D ECL1ICL2 P L A Y K R I V ICL2ECL2 W N C E K L Q S V C S D I F P H I ECL2ICL3 T Q K S I I I H T S E D G K V Q V T R ICL3ECL3 K M ECL3N-term M K S I L D G L A D T T F R T I T T D L L Y V G S N D I Q Y E D I K G D M A S K L G Y F P Q K F P L T S F R G S P F Q E K M T A G D N P Q L V P A D Q V N I T E F Y N K S L S S F K E N E E N I Q C G E N F M D I E C F M V L N-termC-term S C E G T A Q P L D N S M G D S D C L H K H A N N A A S V H R A A E S C I K S T V K I A K V T M S V S T D T S A E A L C-term N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I L H S R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R T R P K A V V A F C L M W T I A I V I A V L P L L G D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R G P D Q A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D F R S L R H A M F P
Helix box plot — Download: PNG | SVG L N E L V T F T G L T L S L V A I A L Q 1 G S L A V A D L L G S V I F V Y S F I D 2 L F L S G V S A T F S A T V G G L K F L 3 A V V A F C L M W T I A I V I A V L P L 4 Y A Y V I F L L L V S T V G I W F M L Y 5 V L I L V V L I I C W G P L L A I M V Y 6 I P N V T S N L L C L M S C F A F V T 7

GPCRdb(A)
GPCRdb(A)
CB1 receptor
TM3
3x28 3.28x28 K192
3x29 3.29x29 L193
3x32 3.32x32 V196
3x33 3.33x33 T197
3x36 3.36x36 F200
TM5
5x39 5.39x39 Y275
5x40 5.40x40 L276
5x43 5.43x43 W279
TM6
6x47 6.47x47 C355
6x48 6.48x48 W356
6x51 6.51x51 L359
6x52 6.52x52 L360
6x55 6.55x55 M363
TM7
7x38 7.39x38 S383
7x41 7.42x41 C386
7x45 7.45x45 N389