PDB
9BLW
Resolution
3.2 Å
Released
April 16, 2025
Receptor
CT
Class
B1
Species
Homo sapiens
Ligand
Cagrilintide backbone (non-acylated)
Function
Agonist
Reference
10.1038/S41467-025-58680-Y

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
Cagrilintide backbone (non-acylated) W79 N-term hydrophobic
Cagrilintide backbone (non-acylated) F99 N-term polar (hydrogen bond with backbone)
Cagrilintide backbone (non-acylated) F99 N-term Van der Waals
Cagrilintide backbone (non-acylated) P100 N-term Van der Waals
Cagrilintide backbone (non-acylated) P100 N-term polar (hydrogen bond with backbone)
Cagrilintide backbone (non-acylated) D101 N-term polar (charge-assisted hydrogen bond)
Cagrilintide backbone (non-acylated) F102 N-term polar (hydrogen bond with backbone)
Cagrilintide backbone (non-acylated) F102 N-term Van der Waals
Cagrilintide backbone (non-acylated) P104 N-term Van der Waals
Cagrilintide backbone (non-acylated) H121 N-term Van der Waals
Cagrilintide backbone (non-acylated) N124 N-term Van der Waals
Cagrilintide backbone (non-acylated) N124 N-term polar (hydrogen bond)
Cagrilintide backbone (non-acylated) R126 N-term polar (charge-assisted hydrogen bond)
Cagrilintide backbone (non-acylated) T127 N-term polar (hydrogen bond with backbone)
Cagrilintide backbone (non-acylated) T127 N-term Van der Waals
Cagrilintide backbone (non-acylated) W128 N-term Van der Waals
Cagrilintide backbone (non-acylated) W128 N-term hydrophobic
Cagrilintide backbone (non-acylated) S129 N-term polar (hydrogen bond)
Cagrilintide backbone (non-acylated) S129 N-term polar (hydrogen bond with backbone)
Cagrilintide backbone (non-acylated) Y131 N-term Van der Waals
Cagrilintide backbone (non-acylated) Y131 N-term hydrophobic
Cagrilintide backbone (non-acylated) N135 1.26x26 TM1 polar (hydrogen bond)
Cagrilintide backbone (non-acylated) N135 1.26x26 TM1 Van der Waals
Cagrilintide backbone (non-acylated) K141 1.32x32 TM1 Van der Waals
Cagrilintide backbone (non-acylated) L142 1.33x33 TM1 Van der Waals
Cagrilintide backbone (non-acylated) L142 1.33x33 TM1 hydrophobic
Cagrilintide backbone (non-acylated) A145 1.36x36 TM1 Van der Waals
Cagrilintide backbone (non-acylated) A145 1.36x36 TM1 hydrophobic
Cagrilintide backbone (non-acylated) Y146 1.37x37 TM1 hydrophobic
Cagrilintide backbone (non-acylated) Y146 1.37x37 TM1 Van der Waals
Cagrilintide backbone (non-acylated) Y149 1.40x40 TM1 Van der Waals
Cagrilintide backbone (non-acylated) Y149 1.40x40 TM1 aromatic (face-to-edge)
Cagrilintide backbone (non-acylated) V206 ECL1 Van der Waals
Cagrilintide backbone (non-acylated) V206 ECL1 hydrophobic
Cagrilintide backbone (non-acylated) P207 ECL1 hydrophobic
Cagrilintide backbone (non-acylated) P207 ECL1 Van der Waals
Cagrilintide backbone (non-acylated) H226 3.36x36 TM3 polar (hydrogen bond)
Cagrilintide backbone (non-acylated) Q227 3.37x37 TM3 polar (hydrogen bond)
Cagrilintide backbone (non-acylated) Y234 3.44x44 TM3 hydrophobic
Cagrilintide backbone (non-acylated) Y234 3.44x44 TM3 Van der Waals
Cagrilintide backbone (non-acylated) L291 45.52x52 ECL2 Van der Waals
Cagrilintide backbone (non-acylated) L291 45.52x52 ECL2 polar (hydrogen bond with backbone)
Cagrilintide backbone (non-acylated) V293 ECL2 Van der Waals
Cagrilintide backbone (non-acylated) V293 ECL2 hydrophobic
Cagrilintide backbone (non-acylated) E294 ECL2 Van der Waals
Cagrilintide backbone (non-acylated) H296 ECL2 Van der Waals
Cagrilintide backbone (non-acylated) Y299 5.37x38 TM5 polar (hydrogen bond)
Cagrilintide backbone (non-acylated) Y299 5.37x38 TM5 polar (hydrogen bond)
Cagrilintide backbone (non-acylated) H302 5.40x40 TM5 polar (hydrogen bond)
Cagrilintide backbone (non-acylated) F356 6.53x53 TM6 hydrophobic
Cagrilintide backbone (non-acylated) F356 6.53x53 TM6 Van der Waals
Cagrilintide backbone (non-acylated) F359 6.56x56 TM6 Van der Waals
Cagrilintide backbone (non-acylated) P360 ECL3 Van der Waals
Cagrilintide backbone (non-acylated) P360 ECL3 polar (hydrogen bond with backbone)
Cagrilintide backbone (non-acylated) W361 ECL3 hydrophobic
Cagrilintide backbone (non-acylated) W361 ECL3 Van der Waals
Cagrilintide backbone (non-acylated) R362 ECL3 Van der Waals
Cagrilintide backbone (non-acylated) H377 7.43x42 TM7 polar (hydrogen bond)
Cagrilintide backbone (non-acylated) H377 7.43x42 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 R S L G ICL1ECL1 V P N G E L V R R D ECL1ICL2 A V F T E K Q ICL2ECL2 N D N C W L S V E T H L ECL2ICL3 E ICL3ECL3 R P S ECL3N-term M R F T F T S R C L A L F L L L N H P T P I L P A F S N Q T Y P T I E P K P F L Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y N-termC-term P S N R S A R A A A A A A E A G D I P I Y I C H Q E L R N E P A N N Q G E E S A E I I P L N I I E Q E S S A C-term T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V K R F K I R W G V Q T T Q W A Q Q W N Q R R
Helix box plot — Download: PNG | SVG V L T F I S L S H G V I A L Y Y L V Y A 1 K N M F L T Y I L N S M I I I I H L V E 2 C L M W F Y N C A M M Y Q H F F H L I K 3 R L R W Y Y L G L W G F P L V P T T I H A 4 L F F F N V V L A A M V P G H I I Y L 5 M I L V P L L G I Q F V V F P W 6 T A V F F G Q F H I L S H M V Y D Y I 7

GPCRdb(A)
GPCRdb(B)
CT receptor
TM1
1x22 1.26x26 N135
1x28 1.32x32 K141
1x29 1.33x33 L142
1x32 1.36x36 A145
1x33 1.37x37 Y146
1x36 1.40x40 Y149
TM3
3x32 3.36x36 H226
3x33 3.37x37 Q227
3x40 3.44x44 Y234
ECL2
45x52 45.52x52 L291
TM5
5x42 5.37x38 Y299
5x44 5.40x40 H302
TM6
6x48 6.53x53 F356
6x51 6.56x56 F359
TM7
7x38 7.43x42 H377