PDB
9BUY
Resolution
2.9 Å
Released
May 28, 2025
Receptor
β2
Class
A
Species
Homo sapiens
Ligands
LM189
compound-6FA
Function
Agonist
PAM
Reference
—
LM189 compound-6FA

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Ligand Amino Acid Generic Number Segment Interaction Type
LM189 W109 3.28x28 TM3 hydrophobic
LM189 D113 3.32x32 TM3 polar (charge-assisted hydrogen bond)
LM189 V114 3.33x33 TM3 Van der Waals
LM189 V114 3.33x33 TM3 hydrophobic
LM189 V117 3.36x36 TM3 Van der Waals
LM189 V117 3.36x36 TM3 hydrophobic
compound-6FA V129 3.48x48 TM3 hydrophobic
compound-6FA F133 3.52x52 TM3 aromatic (face-to-edge)
compound-6FA Y141 34.53x53 ICL2 hydrophobic
compound-6FA L144 34.56x56 ICL2 hydrophobic
compound-6FA I153 4.45x45 TM4 hydrophobic
LM189 D192 45.51x51 ECL2 Van der Waals
LM189 F193 45.52x52 ECL2 Van der Waals
LM189 F193 45.52x52 ECL2 hydrophobic
LM189 F194 ECL2 Van der Waals
LM189 F194 ECL2 hydrophobic
LM189 S203 5.42x43 TM5 polar (hydrogen bond)
LM189 S203 5.42x43 TM5 Van der Waals
LM189 S207 5.46x461 TM5 Van der Waals
LM189 F289 6.51x51 TM6 Van der Waals
LM189 F289 6.51x51 TM6 hydrophobic
LM189 N293 6.55x55 TM6 polar (hydrogen bond)
LM189 N293 6.55x55 TM6 Van der Waals
LM189 I303 ECL3 Van der Waals
LM189 R304 7.31x30 TM7 Van der Waals
LM189 K305 7.32x31 TM7 Van der Waals
LM189 Y308 7.35x34 TM7 Van der Waals
LM189 Y308 7.35x34 TM7 hydrophobic
LM189 I309 7.36x35 TM7 Van der Waals
LM189 I309 7.36x35 TM7 hydrophobic
LM189 N312 7.39x38 TM7 polar (hydrogen bond)
LM189 Y316 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 E R L Q ICL1ECL1 M W T F ECL1ICL2 P F K Y Q S L L ICL2ECL2 W Y R A T H Q E A I N C Y A N E T C C D F F T ECL2ICL3 G R F H V Q N L S Q V E Q D G R T G H G L R R S ICL3ECL3 D N L I ECL3N-term M G Q P G N G S A F L L A P N G S H A P D H D V T N-termC-term L R R S S L K A Y G N G Y S S N G N T G E Q S G Y H V E Q E K E N K L L C E D L P G T E D F V G H Q G T V P S D N I D S Q G R N C S T N D S L L C-term Q E R D E V W V V G M G I V M S L I V L A I V F G N V L V I T A I A K F T V T N Y F I T S L A C A D L V M G L A V V P F G A A H I L M K G N F W C E F W T S I D V L C V T A S I E T L C V I A V D R Y F A I T S T K N K A R V I I L M V W I V S G L T S F L P I Q M H N Q A Y A I A S S I V S F Y V P L V I M V F V Y S R V F Q E A K R Q L Q K I D K S E S K F C L K E H K A L K T L G I I M G T F T L C W L P F F I V N I V H V I Q R K E V Y I L L N W I G Y V N S G F N P L I Y C R S P D F Q E F R I A L L C
Helix box plot — Download: PNG | SVG V N G F V I A L V I L S M V I G M G V V 1 T S L A C A D L V M G A L V V P F G A A H 2 V C L T E I S A T V C L V D I S T W F E 3 A R V I I L M V W I V S G L T S F L P I 4 Y V F V M I V L P V Y F S V I S S A I A Y 5 G I I M G T F T L C W L P F F I V N I V 6 L P N F G S N V Y G I W N L L I Y V E 7

GPCRdb(A)
GPCRdb(A)
β2-adrenoceptor
TM3
3x28 3.28x28 W109
3x32 3.32x32 D113
3x33 3.33x33 V114
3x36 3.36x36 V117
3x48 3.48x48 V129
3x52 3.52x52 F133
ICL2
34x53 34.53x53 Y141
34x56 34.56x56 L144
TM4
4x45 4.45x45 I153
ECL2
45x51 45.51x51 D192
45x52 45.52x52 F193
TM5
5x43 5.42x43 S203
5x461 5.46x461 S207
TM6
6x51 6.51x51 F289
6x55 6.55x55 N293
TM7
7x30 7.31x30 R304
7x31 7.32x31 K305
7x34 7.35x34 Y308
7x35 7.36x35 I309
7x38 7.39x38 N312
7x42 7.43x42 Y316