PDB
9CGK
Resolution
2.6 Å
Released
April 2, 2025
Receptor
δ
Class
A
Species
Homo sapiens
Ligand
C5-Quino
Function
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
C5-Quino Y129 3.33x33 TM3 polar (hydrogen bond)
C5-Quino Y129 3.33x33 TM3 Van der Waals
C5-Quino M132 3.36x36 TM3 Van der Waals
C5-Quino S135 3.39x39 TM3 Van der Waals
C5-Quino S135 3.39x39 TM3 polar (hydrogen bond)
C5-Quino W274 6.48x48 TM6 hydrophobic
C5-Quino W274 6.48x48 TM6 Van der Waals
C5-Quino I277 6.51x51 TM6 hydrophobic
C5-Quino I277 6.51x51 TM6 Van der Waals
C5-Quino H278 6.52x52 TM6 Van der Waals
C5-Quino H278 6.52x52 TM6 aromatic (face-to-edge)
C5-Quino V281 6.55x55 TM6 Van der Waals
C5-Quino V281 6.55x55 TM6 hydrophobic
C5-Quino W284 6.58x58 TM6 aromatic (face-to-edge)
C5-Quino W284 6.58x58 TM6 Van der Waals
C5-Quino L300 7.35x34 TM7 hydrophobic
C5-Quino I304 7.39x38 TM7 hydrophobic
C5-Quino I304 7.39x38 TM7 Van der Waals
C5-Quino G307 7.42x41 TM7 Van der Waals
C5-Quino Y308 7.43x42 TM7 hydrophobic
C5-Quino Y308 7.43x42 TM7 Van der Waals
C5-Quino N310 7.45x45 TM7 polar (hydrogen bond)
C5-Quino N310 7.45x45 TM7 Van der Waals
C5-Quino S311 7.46x46 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 V T R P R D G A V V C M L Q F P S ECL2ICL3 R L L S G ICL3ECL3 D I D R R ECL3N-term M E P A P S A G A E L Q P P L F A N A S D A Y P S A C P S A G A N A S G P P N-termC-term P C G R P D P S S F S R A R E A T A R E R V T A C T P S D G P G G G A A A C-term G A R S A S S L A L A I A I T A L Y S A V C A V G L L G N V L V M F G I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S A K Y L M E G E L L C K A V L S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H T P A K A K L I N I C I W V L A S G V G V P I M V M A P S W Y W D T V T K I C V F L F A F V V P I L I I T V C Y G L M L L R L R S V S K E K D R S L R R I T R M V L V V V G A F V V C W A P I H I F V I V W T L V D P L V V A A L H L C I A L G Y A N S S L N P V L Y A F L D E N F R Q F K R C L C R K
Helix box plot — Download: PNG | SVG V N G L L G V A C V A S Y L A T I A I A 1 F N L A L A D A L A T S T L P F Q S A K 2 M T L T F I S T F M N Y Y D I S L V A K 3 A K L I N I C I W V L A S G V G V P I M 4 Y C V T I I L I P V V F A F L F V C I K T 5 L V V V G A F V V C W A P I H I F V I V 6 V P N L S S N A Y G L A I C L H L A A 7

GPCRdb(A)
GPCRdb(A)
δ receptor
TM3
3x33 3.33x33 Y129
3x36 3.36x36 M132
3x39 3.39x39 S135
TM6
6x48 6.48x48 W274
6x51 6.51x51 I277
6x52 6.52x52 H278
6x55 6.55x55 V281
6x58 6.58x58 W284
TM7
7x34 7.35x34 L300
7x38 7.39x38 I304
7x41 7.42x41 G307
7x42 7.43x42 Y308
7x45 7.45x45 N310
7x46 7.46x46 S311