PDB
9CLW
Resolution
3.2 Å
Released
June 25, 2025
Receptor
FFA2
Class
A
Species
Homo sapiens
Ligands
Function
CHEMBL4176503
Agonist
AMG7703
Ago-PAM
Reference
—
CHEMBL4176503 AMG7703

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Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL4176503 S86 3.29x29 TM3 Van der Waals
CHEMBL4176503 F87 3.30x30 TM3 hydrophobic
CHEMBL4176503 Y90 3.33x33 TM3 hydrophobic
CHEMBL4176503 Y94 3.37x37 TM3 hydrophobic
CHEMBL4176503 C141 4.57x57 TM4 hydrophobic
CHEMBL4176503 V144 4.60x60 TM4 hydrophobic
CHEMBL4176503 I145 4.61x61 TM4 hydrophobic
CHEMBL4176503 V147 4.63x63 TM4 hydrophobic
CHEMBL4176503 Q148 4.64x64 TM4 hydrophobic
CHEMBL4176503 Y165 45.51x51 ECL2 hydrophobic
CHEMBL4176503 F168 ECL2 hydrophobic
CHEMBL4176503 V175 5.34x35 TM5 hydrophobic
CHEMBL4176503 V176 5.35x36 TM5 hydrophobic
CHEMBL4176503 V179 5.38x39 TM5 hydrophobic
CHEMBL4176503 R180 5.39x40 TM5 polar (charge-charge)
CHEMBL4176503 R180 5.39x40 TM5 polar (hydrogen bond)
CHEMBL4176503 L183 5.42x43 TM5 Van der Waals
AMG7703 V226 6.39x40 TM6 hydrophobic
AMG7703 L229 6.42x43 TM6 Van der Waals
AMG7703 N230 6.43x44 TM6 polar (hydrogen bond)
AMG7703 V233 6.46x461 TM6 hydrophobic
AMG7703 C234 6.47x47 TM6 Van der Waals
CHEMBL4176503 Y238 6.51x51 TM6 polar (hydrogen bond)
CHEMBL4176503 H242 6.55x55 TM6 Van der Waals
CHEMBL4176503 R255 7.35x34 TM7 polar (charge-charge)
CHEMBL4176503 R255 7.35x34 TM7 polar (hydrogen bond)
AMG7703 F261 7.41x40 TM7 hydrophobic
AMG7703 L264 7.44x43 TM7 hydrophobic
AMG7703 L268 7.48x48 TM7 Van der Waals
AMG7703 L272 7.52x52 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 P Q P ICL1ECL1 N F R W Y L ECL1ICL2 P V Q Y K L S R ICL2ECL2 T E Q V R S G N E I T C Y E N F T D N ECL2ICL3 P L V ICL3ECL3 K S P W ECL3N-term M L N-termC-term R N Q G S S L L G R R G K D T A E G T N E D R G V G Q G E G M P S S D F T T E C-term P D W K S S L I L M A Y I I I F L T G L P A N L L A L R A F V G R I R Q A P V H I L L L S L T L A D L L L L L L L P F K I I E A A S P K V V C A L T S F G F Y S S I Y C S T W L L A G I S I E R Y L G V A F R P L Y G V I A A L V A W V M S F G H C T I V I I V Q Y L N T Q L D V V L P V R L E L C L V L F F I P M A V T I F C Y W R F V W I M L S Q G A Q R R R R A V G L A V V T L L N F L V C F G P Y N V S H L V G Y H Q R W R S I A V V F S S L N A S L D P L L F Y F S S S V F G R L V R R A G L Q V
Helix box plot — Download: PNG | SVG L N A P L G T L F I I I Y A M L I L S S 1 L S L T L A D L L L L L L L P F K I I E 2 G A L L W T S C Y I S S Y F G F S T L A 3 G V I A A L V A W V M S F G H C T I V I 4 Y C F I T V A M P I F F L V L C L E L R V 5 A V V T L L N F V L C F G P Y N V S H L V 6 L P D L S A N L S S F V V A I S R W 7

GPCRdb(A)
GPCRdb(A)
FFA2 receptor
TM3
3x29 3.29x29 S86
3x30 3.30x30 F87
3x33 3.33x33 Y90
3x37 3.37x37 Y94
TM4
4x57 4.57x57 C141
4x60 4.60x60 V144
4x61 4.61x61 I145
4x63 4.63x63 V147
4x64 4.64x64 Q148
ECL2
45x51 45.51x51 Y165
TM5
5x35 5.34x35 V175
5x36 5.35x36 V176
5x39 5.38x39 V179
5x40 5.39x40 R180
5x43 5.42x43 L183
TM6
6x40 6.39x40 V226
6x43 6.42x43 L229
6x44 6.43x44 N230
6x461 6.46x461 V233
6x47 6.47x47 C234
6x51 6.51x51 Y238
6x55 6.55x55 H242
TM7
7x34 7.35x34 R255
7x40 7.41x40 F261
7x43 7.44x43 L264
7x48 7.48x48 L268
7x52 7.52x52 L272