PDB
9E7R
Resolution
3.2 Å
Released
May 7, 2025
Receptor
PAR2
Class
A
Species
Homo sapiens
Ligand
GB88
Function
Agonist (partial)
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
GB88 V61 N-term hydrophobic
GB88 V68 N-term hydrophobic
GB88 H227 45.51x51 ECL2 aromatic (face-to-edge)
GB88 D228 45.52x52 ECL2 Van der Waals
GB88 D228 45.52x52 ECL2 polar (hydrogen bond with backbone)
GB88 V229 ECL2 hydrophobic
GB88 V229 ECL2 Van der Waals
GB88 L230 ECL2 Van der Waals
GB88 L230 ECL2 polar (hydrogen bond with backbone)
GB88 P231 ECL2 hydrophobic
GB88 E232 ECL2 Van der Waals
GB88 L235 5.31x32 TM5 Van der Waals
GB88 L235 5.31x32 TM5 hydrophobic
GB88 H310 6.58x58 TM6 Van der Waals
GB88 H310 6.58x58 TM6 polar (hydrogen bond)
GB88 Y311 6.59x59 TM6 Van der Waals
GB88 Y311 6.59x59 TM6 polar (hydrogen bond)
GB88 I314 6.62x62 TM6 Van der Waals
GB88 S320 ECL3 polar (hydrogen bond)
GB88 S320 ECL3 Van der Waals
GB88 Y323 7.32x31 TM7 Van der Waals
GB88 Y323 7.32x31 TM7 aromatic (face-to-face)

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Snake plot — Download: PNG | SVG
ICL1 T K K K ICL1ECL1 G N N W I Y ECL1ICL2 P M G H S R K ICL2ECL2 V K Q T I F I P A L N I T T C H D V L P E Q L ECL2ICL3 A M D ICL3ECL3 G Q S H ECL3N-term M R S P S A A W L L G A A I L L A A S L S C S G T I Q G T N R S S K G R S L I G K V D G T S H V T G K G V T V E T V F S V D E F S A S V L T N-termC-term S V R T V K Q M Q V S L T S K K H S R K S S S Y S S S S T T V K T S Y C-term G K L T T V F L P I V Y T I V F V V G L P S N G M A L W V F L F R H P A V I Y M A N L A L A D L L S V I W F P L K I A Y H I H G E A L C N V L I G F F Y G N M Y C S I L F M T C L S V Q R Y W V I V N K A N I A I G I S L A I W L L I L L V T I P L Y V L V G D M F N Y F L S L A I G V F L F P A F L T A S A Y V L M I R M L R S S E N S E K K R K R A I K L I V T V L A M Y L I C F T P S N L L L V V H Y F L I K S Q V Y A L Y I V A L C L S T L N S C I D P F V Y Y F V S H D A K N R F R D H A L L C
Helix box plot — Download: PNG | SVG G N S P L G V V F V I T Y V I P L F V T 1 A N L A L A D L L S V I W F P L K I A Y 2 C T M F L I S C Y M N G Y F F G I L V N 3 A I G I S L A I W L L I L L V T I P L 4 Y A S A T L F A P F L F V G I A L S L F Y 5 I V T V L A M Y I L C F T P S N L L L V V 6 F P D I C S N L T S L C L A V I Y L A 7

GPCRdb(A)
GPCRdb(A)
PAR2
ECL2
45x51 45.51x51 H227
45x52 45.52x52 D228
TM5
5x32 5.31x32 L235
TM6
6x58 6.58x58 H310
6x59 6.59x59 Y311
6x62 6.62x62 I314
TM7
7x31 7.32x31 Y323