PDB
9EAJ
Resolution
3.2 Å
Released
March 5, 2025
Receptor
AT1
Class
A
Species
Homo sapiens
Ligand
Nanobody AT206
Function
PAM
Reference
10.1073/PNAS.2423931122

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Ligand Amino Acid Generic Number Segment Interaction Type
Nanobody AT206 Y35 1.39x39 TM1 aromatic (face-to-face)
Nanobody AT206 W84 2.60x60 TM2 hydrophobic
Nanobody AT206 Y87 2.63x63 TM2 hydrophobic
Nanobody AT206 Y92 ECL1 aromatic (face-to-face)
Nanobody AT206 R167 ECL2 polar (charge-assisted hydrogen bond)
Nanobody AT206 F170 ECL2 Van der Waals
Nanobody AT206 F170 ECL2 aromatic (edge-to-face)
Nanobody AT206 I172 ECL2 Van der Waals
Nanobody AT206 I172 ECL2 hydrophobic
Nanobody AT206 E173 ECL2 polar (charge-assisted hydrogen bond)
Nanobody AT206 N174 ECL2 Van der Waals
Nanobody AT206 N174 ECL2 polar (hydrogen bond)
Nanobody AT206 V179 ECL2 hydrophobic
Nanobody AT206 V179 ECL2 Van der Waals
Nanobody AT206 A181 45.51x51 ECL2 hydrophobic
Nanobody AT206 A181 45.51x51 ECL2 Van der Waals
Nanobody AT206 F182 45.52x52 ECL2 polar (hydrogen bond with backbone)
Nanobody AT206 F182 45.52x52 ECL2 Van der Waals
Nanobody AT206 H183 ECL2 polar (hydrogen bond)
Nanobody AT206 H183 ECL2 aromatic (face-to-face)
Nanobody AT206 Y184 ECL2 polar (hydrogen bond with backbone)
Nanobody AT206 Y184 ECL2 Van der Waals
Nanobody AT206 E185 ECL2 Van der Waals
Nanobody AT206 S186 ECL2 Van der Waals
Nanobody AT206 S189 ECL2 Van der Waals
Nanobody AT206 P192 5.35x36 TM5 Van der Waals
Nanobody AT206 P192 5.35x36 TM5 hydrophobic
Nanobody AT206 D1263 6.58x58 TM6 polar (charge-assisted hydrogen bond)
Nanobody AT206 Q1267 6.62x62 TM6 Van der Waals
Nanobody AT206 Q1267 6.62x62 TM6 polar (hydrogen bond)
Nanobody AT206 D1281 7.32x31 TM7 polar (charge-assisted hydrogen bond)
Nanobody AT206 M1284 7.35x34 TM7 Van der Waals
Nanobody AT206 M1284 7.35x34 TM7 hydrophobic
Nanobody AT206 P1285 7.36x35 TM7 hydrophobic
Nanobody AT206 P1285 7.36x35 TM7 Van der Waals
Nanobody AT206 I1288 7.39x38 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 M K L K ICL1ECL1 Y R W P F ECL1ICL2 P M K S R L R R ICL2ECL2 N V F F I E N T N I T V C A F H Y E S Q N S T ECL2ICL3 Y E I Q K N K ICL3ECL3 I I R ECL3N-term M I L N S S T E D G I K R I Q D D C P K A G R N-termC-term P P K A K S H S N L S T K M S T L S Y R P S D N V S S S T K K P A P C F E V E C-term H N Y I F V M I P T L Y S I I F V V G I F G N S L V V I V I Y F Y T V A S V F L L N L A L A D L C F L L T L P L W A V Y T A M E G N Y L C K I A S A S V S F N L Y A S V F L L T C L S I D R Y L A I V H T M L V A K V T C I I I W L L A G L A S L P A I I H R L P I G L G L T K N I L G F L F P F L I I L T S Y T L I W K A L K K A P R N D D I F K I I M A I V L F F F F S W I P H Q I F T F L D V L I Q L G D C R I A D I V D T A M P I T I C I A Y F N N C L N P L F Y G F L G K K F L Q I F K R Y L L K Y
Helix box plot — Download: PNG | SVG S N G F I G V V F I I S Y L T P I M V F 1 L N L A L A D L C F L L T L P L W A V Y 2 C T L L F V S A Y L N F S V S A S A I K 3 A K V T C I I I W L L A G L A S L P A 4 Y S T L I I L F P F L F G L I N K T L G L 5 M A I V L F F F F S W I P H Q I F T F L 6 L P N L C N N F Y A I C I T I P M A T 7

GPCRdb(A)
GPCRdb(A)
AT1 receptor
TM1
1x39 1.39x39 Y35
TM2
2x60 2.60x60 W84
2x63 2.63x63 Y87
ECL2
45x51 45.51x51 A181
45x52 45.52x52 F182
TM5
5x36 5.35x36 P192
TM6
6x58 6.58x58 D263
6x62 6.62x62 Q267
TM7
7x31 7.32x31 D281
7x34 7.35x34 M284
7x35 7.36x35 P285
7x38 7.39x38 I288