PDB
9EJZ
Resolution
2.1 Å
Released
Aug. 13, 2025
Receptor
M5
Class
A
Species
Homo sapiens
Ligands
acetylcholine
VU6007678
Function
Agonist
Ago-PAM
Reference
—
acetylcholine VU6007678

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Ligand Amino Acid Generic Number Segment Interaction Type
acetylcholine Y111 3.33x33 TM3 hydrophobic
VU6007678 V123 3.45x45 TM3 hydrophobic
VU6007678 F126 3.48x48 TM3 hydrophobic
VU6007678 F130 3.52x52 TM3 aromatic (edge-to-face)
VU6007678 R134 3.56x56 TM3 polar (charge-assisted hydrogen bond)
VU6007678 Y138 ICL2 Van der Waals
VU6007678 Y138 ICL2 hydrophobic
VU6007678 K141 ICL2 polar (charge-assisted hydrogen bond)
VU6007678 R146 4.41x41 TM4 polar (charge-assisted hydrogen bond)
VU6007678 I149 4.44x44 TM4 Van der Waals
VU6007678 M150 4.45x45 TM4 Van der Waals
VU6007678 M150 4.45x45 TM4 hydrophobic
acetylcholine W162 4.57x57 TM4 hydrophobic
acetylcholine W455 6.48x48 TM6 hydrophobic
acetylcholine Y458 6.51x51 TM6 hydrophobic
acetylcholine Y481 7.39x38 TM7 hydrophobic
acetylcholine Y485 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 S Q L K ICL1ECL1 R W A L ECL1ICL2 P L T Y R A K R ICL2ECL2 K R T V P L D E C Q I Q F L S ECL2ICL3 Q G S D S V T K A E K R K P A H R A L F R S C L R C P R P T L A Q R E R N Q A S W S S S R R S T S T T G K P S Q A T G P S A N W A K A E Q L T T C S S Y P S S E D E D K P A T D P V L Q V V Y K S Q G K E S P G E E F S A E E T E E T F V K A E T E K S D Y D T P N Y L L S P A A A H R P K S Q K C V A Y K F R L V V K A D G N Q E T N N G C H K V K I M P C P F P V A K E P S T K G L N P N P S H Q M T K R K ICL3ECL3 D K C V ECL3N-term M E G D S Y H N A T T V N G T P V N H Q P L E R H N-termC-term C R W K K K K V E E K L Y W Q G N S K L P C-term R L W E V I T I A A V T A V V S L I T I V G N V L V M I S F K V N T V N N Y Y L L S L A C A D L I I G I F S M N L Y T T Y I L M G G S L A C D L W L A L D Y V A S N A S V M N L L V I S F D R Y F S I T R T P K R A G I M I G L A W L I S F I L W A P A I L C W Q Y L V G E P T I T F G T A I A A F Y I P V S V M T I L Y C R I Y R E T E K R T K D L A D L R V V L V K E R K A A Q T L S A I L L A F I I T W T P Y N I M V L V S T F C P V T L W H L G Y W L C Y V N S T V N P I C Y A L C N R T F K M F R K T L L L
Helix box plot — Download: PNG | SVG V N G V I T I L S V V A T V A A I T I V 1 L S L A C A D L I I G F I S M N L Y T T Y 2 V L L N M V S A N S A V Y D L A L W L D 3 A G I M I G L A W L I S F I L W A P A I 4 Y L I T M V S V P I Y F A A I A T G F T I 5 S A I L L A F I I T W T P Y N I M V L V 6 I P N V T S N V Y C L W Y G L H W L T 7

GPCRdb(A)
GPCRdb(A)
M5 receptor
TM3
3x33 3.33x33 Y111
3x45 3.45x45 V123
3x48 3.48x48 F126
3x52 3.52x52 F130
3x56 3.56x56 R134
TM4
4x41 4.41x41 R146
4x44 4.44x44 I149
4x45 4.45x45 M150
4x57 4.57x57 W162
TM6
6x48 6.48x48 W455
6x51 6.51x51 Y458
TM7
7x38 7.39x38 Y481
7x42 7.43x42 Y485