PDB
9EK0
Resolution
2.8 Å
Released
Oct. 8, 2025
Receptor
M5
Class
A
Species
Homo sapiens
Ligand
iperoxo
Function
Agonist
Reference
10.1038/S41467-025-62212-Z

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Ligand Amino Acid Generic Number Segment Interaction Type
iperoxo Y111 3.33x33 TM3 hydrophobic
iperoxo V118 3.40x40 TM3 hydrophobic
iperoxo W162 4.57x57 TM4 hydrophobic
iperoxo A201 5.46x461 TM5 hydrophobic
iperoxo W455 6.48x48 TM6 hydrophobic
iperoxo Y458 6.51x51 TM6 hydrophobic
iperoxo Y481 7.39x38 TM7 hydrophobic
iperoxo Y485 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 S Q L K ICL1ECL1 R W A L ECL1ICL2 P L T Y R A K R ICL2ECL2 K R T V P L D E C Q I Q F L S ECL2ICL3 Q G S D S V T K A E K R K P A H R A L F R S C L R C P R P T L A Q R E R N Q A S W S S S R R S T S T T G K P S Q A T G P S A N W A K A E Q L T T C S S Y P S S E D E D K P A T D P V L Q V V Y K S Q G K E S P G E E F S A E E T E E T F V K A E T E K S D Y D T P N Y L L S P A A A H R P K S Q K C V A Y K F R L V V K A D G N Q E T N N G C H K V K I M P C P F P V A K E P S T K G L N P N P S H Q M T K R K ICL3ECL3 D K C V ECL3N-term M E G D S Y H N A T T V N G T P V N H Q P L E R H N-termC-term C R W K K K K V E E K L Y W Q G N S K L P C-term R L W E V I T I A A V T A V V S L I T I V G N V L V M I S F K V N T V N N Y Y L L S L A C A D L I I G I F S M N L Y T T Y I L M G G S L A C D L W L A L D Y V A S N A S V M N L L V I S F D R Y F S I T R T P K R A G I M I G L A W L I S F I L W A P A I L C W Q Y L V G E P T I T F G T A I A A F Y I P V S V M T I L Y C R I Y R E T E K R T K D L A D L R V V L V K E R K A A Q T L S A I L L A F I I T W T P Y N I M V L V S T F C P V T L W H L G Y W L C Y V N S T V N P I C Y A L C N R T F K M F R K T L L L
Helix box plot — Download: PNG | SVG V N G V I T I L S V V A T V A A I T I V 1 L S L A C A D L I I G F I S M N L Y T T Y 2 V L L N M V S A N S A V Y D L A L W L D 3 A G I M I G L A W L I S F I L W A P A I 4 Y L I T M V S V P I Y F A A I A T G F T I 5 S A I L L A F I I T W T P Y N I M V L V 6 I P N V T S N V Y C L W Y G L H W L T 7

GPCRdb(A)
GPCRdb(A)
M5 receptor
TM3
3x33 3.33x33 Y111
3x40 3.40x40 V118
TM4
4x57 4.57x57 W162
TM5
5x461 5.46x461 A201
TM6
6x48 6.48x48 W455
6x51 6.51x51 Y458
TM7
7x38 7.39x38 Y481
7x42 7.43x42 Y485