PDB
9EKH
Resolution
2.9 Å
Released
Sept. 3, 2025
Receptor
DP1
Class
A
Species
Homo sapiens
Ligand
ONO3030297
Function
Inverse agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
ONO3030297 L79 2.57x57 TM2 hydrophobic
ONO3030297 S80 2.58x58 TM2 polar (hydrogen bond)
ONO3030297 S80 2.58x58 TM2 Van der Waals
ONO3030297 M112 3.32x32 TM3 hydrophobic
ONO3030297 M112 3.32x32 TM3 Van der Waals
ONO3030297 F115 3.35x35 TM3 hydrophobic
ONO3030297 F115 3.35x35 TM3 Van der Waals
ONO3030297 S119 3.39x39 TM3 Van der Waals
ONO3030297 W182 ECL2 polar (hydrogen bond)
ONO3030297 W182 ECL2 Van der Waals
ONO3030297 R310 7.40x39 TM7 polar (charge-assisted hydrogen bond)
ONO3030297 L312 7.42x41 TM7 hydrophobic
ONO3030297 L312 7.42x41 TM7 Van der Waals
ONO3030297 S313 7.43x42 TM7 polar (hydrogen bond)
ONO3030297 S316 7.46x46 TM7 polar (hydrogen bond)
ONO3030297 S316 7.46x46 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 G L G W C S R R P L R P L P ICL1ECL1 R S L R V L A ECL1ICL2 P F F Y R R H I ICL2ECL2 F G K F V Q Y C P G T W C F I Q M V H E E G S L S V ECL2ICL3 C A E P R A D G R E ICL3ECL3 D V K E K N ECL3N-term M K S P F Y R C Q N T T S V E K G N N-termC-term R P L R Y R S R C S N S T N M E S S L C-term S A V M G G V L F S T G L L G N L L A L G L L A R S S V F Y M L V C G L T V T D L L G K C L L S P V V L A A Y A Q N P A L D N S L C Q A F A F F M S F F G L S S T L Q L L A M A L E C W L S L G H T L R L G A L V A P V V S A F S L A F C A L P F M G L G Y S V L Y S S L M A L L V L A T V L C N L G A M R N L Y A M H R R L Q R H P R S C T R D A S P Q P L E E L D H L L L L A L M T V L F T M C S L P V I Y R A Y Y G A F K R T S E E A E D L R A L R F L S V I S I V D P W I F I I F R S P F F H V F R I K I F I
Helix box plot — Download: PNG | SVG L N G L L G T S F L V G G M V A S 1 C G L T V T D L L G K C L L S P V V L A 2 A L L Q L T S S L G F F S M F F A F A Q 3 G A L V A P V V S A F S L A F C A L P F 4 G L N C L V T A L V L L A M L S S Y L V 5 A L M T V L F T M C S L P V I Y R A Y Y 6 W P D V I S I V S L F R L A R L D E A 7

GPCRdb(A)
GPCRdb(A)
DP1 receptor
TM2
2x57 2.57x57 L79
2x58 2.58x58 S80
TM3
3x32 3.32x32 M112
3x35 3.35x35 F115
3x39 3.39x39 S119
TM7
7x39 7.40x39 R310
7x41 7.42x41 L312
7x42 7.43x42 S313
7x46 7.46x46 S316