PDB
9HAP
Resolution
2.5 Å
Released
June 4, 2025
Receptor
V2
Class
A
Species
Homo sapiens
Ligand
CHEMBL4303142
Function
Inverse agonist
Reference
—

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL4303142 Q92 2.57x56 TM2 polar (hydrogen bond)
CHEMBL4303142 K116 3.29x29 TM3 polar (charge-assisted hydrogen bond)
CHEMBL4303142 Q119 3.32x32 TM3 Van der Waals
CHEMBL4303142 M120 3.33x33 TM3 hydrophobic
CHEMBL4303142 M120 3.33x33 TM3 Van der Waals
CHEMBL4303142 Q174 4.60x61 TM4 Van der Waals
CHEMBL4303142 F178 ECL2 hydrophobic
CHEMBL4303142 F178 ECL2 Van der Waals
CHEMBL4303142 I209 5.42x43 TM5 Van der Waals
CHEMBL4303142 I209 5.42x43 TM5 hydrophobic
CHEMBL4303142 W284 6.48x48 TM6 Van der Waals
CHEMBL4303142 W284 6.48x48 TM6 hydrophobic
CHEMBL4303142 F287 6.51x51 TM6 hydrophobic
CHEMBL4303142 F287 6.51x51 TM6 Van der Waals
CHEMBL4303142 Q291 6.55x55 TM6 Van der Waals
CHEMBL4303142 M311 7.39x38 TM7 hydrophobic
CHEMBL4303142 M311 7.39x38 TM7 Van der Waals
CHEMBL4303142 S315 7.43x42 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 H W ICL1ECL1 R F R G ECL1ICL2 P M L A Y R H G ICL2ECL2 A Q R N V E G G S G V T D C W A C F A E P ECL2ICL3 P G G R R R G R R T G S P G E G ICL3ECL3 P E A P L E ECL3N-term M L M A S T T S A V P G H P S L P S L P S N S S Q E R P L D T R N-termC-term R T P P S L G P Q D E S C T T A S S S L A K D T S S C-term D P L L A R A E L A L L S I V F V A V A L S N G L V L A A L A R R G R R G A P I H V F I G H L C L A D L A V A L F Q V L P Q L A W K A T D P D A L C R A V K Y L Q M V G M Y A S S Y M I L A M T L D R H R A I C R S G A H W N R P V L V A W A F S L L L S L P Q L F I F W G R R T Y V T W I A L M V F V A P T L G I A A C Q V L I F R E I H A S L V P G P S E R A H V S A A V A K T V R M T L V I V V V Y V L C W A P F F L V Q L W A A W D G A P F V L L M L L A S L N S C T N P W I Y A S F S S S L R S A R G V S S E L L C C
Helix box plot — Download: PNG | SVG G N S L A V A V F V I S L L A L E A R A 1 G H L C L A D L A V A F L Q V L P Q L A W 2 A L I M Y S S A Y M G V M Q L Y K V A R 3 W N R P V L V A W A F S L L L S L P Q 4 Q C A A I G L T P A V F V M L A I W T V Y 5 L V I V V V Y V L C W A P F F L V Q L W 6 W P N T C S N L S A L L M L L V F P A 7

GPCRdb(A)
GPCRdb(A)
V2 receptor
TM2
2x56 2.57x56 Q92
TM3
3x29 3.29x29 K116
3x32 3.32x32 Q119
3x33 3.33x33 M120
TM4
4x61 4.60x61 Q174
TM5
5x43 5.42x43 I209
TM6
6x48 6.48x48 W284
6x51 6.51x51 F287
6x55 6.55x55 Q291
TM7
7x38 7.39x38 M311
7x42 7.43x42 S315