PDB
9IJR
Resolution
3.9 Å
Released
Sept. 3, 2025
Receptor
GPR52
Class
A
Species
Homo sapiens
Ligand
derivative 17 [Nakahata et al., 2018]
Function
Agonist
Reference
10.1038/S41422-025-01165-W

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Ligand Amino Acid Generic Number Segment Interaction Type
derivative 17 [Nakahata et al., 2018] H33 N-term polar (hydrogen bond)
derivative 17 [Nakahata et al., 2018] Y34 N-term polar (hydrogen bond with backbone)
derivative 17 [Nakahata et al., 2018] Y34 N-term Van der Waals
derivative 17 [Nakahata et al., 2018] V36 N-term hydrophobic
derivative 17 [Nakahata et al., 2018] I41 N-term hydrophobic
derivative 17 [Nakahata et al., 2018] I41 N-term Van der Waals
derivative 17 [Nakahata et al., 2018] I47 1.39x39 TM1 Van der Waals
derivative 17 [Nakahata et al., 2018] I47 1.39x39 TM1 hydrophobic
derivative 17 [Nakahata et al., 2018] C94 2.57x57 TM2 Van der Waals
derivative 17 [Nakahata et al., 2018] H186 ECL2 polar (hydrogen bond with backbone)
derivative 17 [Nakahata et al., 2018] H186 ECL2 Van der Waals
derivative 17 [Nakahata et al., 2018] D188 ECL2 polar (hydrogen bond with backbone)
derivative 17 [Nakahata et al., 2018] D188 ECL2 Van der Waals
derivative 17 [Nakahata et al., 2018] I189 ECL2 polar (hydrogen bond with backbone)
derivative 17 [Nakahata et al., 2018] I189 ECL2 Van der Waals
derivative 17 [Nakahata et al., 2018] F190 ECL2 polar (hydrogen bond with backbone)
derivative 17 [Nakahata et al., 2018] F190 ECL2 Van der Waals
derivative 17 [Nakahata et al., 2018] P296 7.32x31 TM7 hydrophobic
derivative 17 [Nakahata et al., 2018] P296 7.32x31 TM7 Van der Waals
derivative 17 [Nakahata et al., 2018] F300 7.36x35 TM7 aromatic (edge-to-face)
derivative 17 [Nakahata et al., 2018] F300 7.36x35 TM7 Van der Waals
derivative 17 [Nakahata et al., 2018] T303 7.39x38 TM7 Van der Waals

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ICL1 P L L H H ICL1ECL1 S T G V H ECL1ICL2 P L S Y N Q L V ICL2ECL2 G W G K P G Y H G D I F E W C A T S W L T ECL2ICL3 P S H E V D ICL3ECL3 V L D ECL3N-term M N E S R W T E W R I L N M S S G I V N V S E R H S C P L G F G H Y S V V D V N-termC-term V K D Q E A Q E P K P R K R A N S C S I C-term C I F E T V V I V L L T F L I I A G N L T V I F V F H C A Y T T S Y F I Q T M A Y A D L F V G V S C L V P T L S L L H Y E S L T C Q V F G Y I I S V L K S V S M A C L A C I S V D R Y L A I T K T P C R L R I C I I L I W I Y S C L I F L P S F F S A Y F T G F I V C L L Y A P A A F V V C F T Y F H I F K I C R Q H T K E I N D R R A R F S S R E T G H S P D R R Y A M V L F R I T S V F Y M L W L P Y I I Y F L L E S S R N P T L S F L T T W L A I S N S F C N C V I Y S L S N S V L R R M C T F R L G L S E T S C M C
Helix box plot — Download: PNG | SVG L N G A I I L F T L L V I V V T E F I C 1 Q T M A Y A D L F V G V S C L V P T L S 2 C A L C A M S V S K L V S I I Y G F V Q 3 L R I C I I L I W I Y S C L I F L P S 4 T F C V V F A A P A Y L L C V I F G T F Y 5 F R I T S V F Y M L W L P Y I I Y F L L 6 V C N C F S N S I A L W T T L F S L T 7

GPCRdb(A)
GPCRdb(A)
GPR52
TM1
1x39 1.39x39 I47
TM2
2x57 2.57x57 C94
TM7
7x31 7.32x31 P296
7x35 7.36x35 F300
7x38 7.39x38 T303