PDB
9J0B
Resolution
2.9 Å
Released
June 4, 2025
Receptor
P2Y14
Class
A
Species
Homo sapiens
Ligand
UDP-glucose
Function
Agonist
Reference
10.1038/S41421-025-00799-9

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Ligand Amino Acid Generic Number Segment Interaction Type
UDP-glucose D81 2.64x64 TM2 polar (charge-assisted hydrogen bond)
UDP-glucose C94 3.25x25 TM3 polar (hydrogen bond)
UDP-glucose C94 3.25x25 TM3 Van der Waals
UDP-glucose A98 3.29x29 TM3 Van der Waals
UDP-glucose V99 3.30x30 TM3 Van der Waals
UDP-glucose Y102 3.33x33 TM3 polar (hydrogen bond)
UDP-glucose Y106 3.37x37 TM3 Van der Waals
UDP-glucose N156 4.60x60 TM4 polar (hydrogen bond)
UDP-glucose N156 4.60x60 TM4 polar (hydrogen bond)
UDP-glucose C172 45.50x50 ECL2 polar (hydrogen bond)
UDP-glucose C172 45.50x50 ECL2 Van der Waals
UDP-glucose K176 ECL2 polar (charge-assisted hydrogen bond)
UDP-glucose H184 5.36x36 TM5 polar (hydrogen bond)
UDP-glucose N188 5.40x40 TM5 polar (hydrogen bond)
UDP-glucose N188 5.40x40 TM5 Van der Waals
UDP-glucose F191 5.43x43 TM5 Van der Waals
UDP-glucose R253 6.55x55 TM6 polar (charge-assisted hydrogen bond)
UDP-glucose Y256 6.58x58 TM6 polar (hydrogen bond)
UDP-glucose Y256 6.58x58 TM6 Van der Waals
UDP-glucose Q260 6.62x62 TM6 polar (hydrogen bond)
UDP-glucose Q260 6.62x62 TM6 Van der Waals
UDP-glucose R274 7.32x31 TM7 polar (charge-assisted hydrogen bond)
UDP-glucose K277 7.35x34 TM7 polar (charge-assisted hydrogen bond)
UDP-glucose E278 7.36x35 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 P S S ICL1ECL1 L G P ECL1ICL2 P L W T S F I Q ICL2ECL2 N Q S V R E V T Q I K C I E L K S ECL2ICL3 L K S ICL3ECL3 A H Y ECL3N-term M I N S T S T Q P P D E S C S Q N N-termC-term L H I P L K A Q N D L D I S R I K R G N T T L E S T D T L C-term L L I T Q Q I I P V L Y C M V F I A G I L L N G V S G W I F F Y V K S F I I Y L K N I V I A D F V M S L T F P F K I L G D S G W Q L N V F V C R V S A V L F Y V N M Y V S I V F F G L I S F D R Y Y K I V K S V S Y S K L L S V I V W M L M L L L A V P N I I L T E L G R K W H K A S N Y I F V A I F W I V F L L L I V F Y T A I T K K I F K S H S R N S T S V K K K S S R N I F S I V F V F F V C F V P Y H I A R I P Y T K S Q T E S C Q S K E I L R Y M K E F T L L L S A A N V C L D P I I Y F F L C Q P L C K F R E I K
Helix box plot — Download: PNG | SVG G N L L I G A I F V M C Y L V P I I Q Q 1 K N I V I A D F V M S L T F P F K I L G 2 L G F F V I S V Y M N V Y F L V A S V R 3 S K L L S V I V W M L M L L L A V P N I 4 Y F V I L L L F V I W F I A V F I Y N S 5 I F S I V F V F V F C F V P Y H I A R I P 6 I P D L C V N A A S L L L T F E K M Y 7

GPCRdb(A)
GPCRdb(A)
P2Y14 receptor
TM2
2x64 2.64x64 D81
TM3
3x25 3.25x25 C94
3x29 3.29x29 A98
3x30 3.30x30 V99
3x33 3.33x33 Y102
3x37 3.37x37 Y106
TM4
4x60 4.60x60 N156
ECL2
45x50 45.50x50 C172
TM5
5x36 5.36x36 H184
5x40 5.40x40 N188
5x43 5.43x43 F191
TM6
6x55 6.55x55 R253
6x58 6.58x58 Y256
6x62 6.62x62 Q260
TM7
7x31 7.32x31 R274
7x34 7.35x34 K277
7x35 7.36x35 E278