PDB
9J0F
Resolution
2.8 Å
Released
June 4, 2025
Receptor
P2Y14
Class
A
Species
Homo sapiens
Ligand
Function
NADH
Agonist
Reference
10.1038/S41421-025-00799-9

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Ligand Amino Acid Generic Number Segment Interaction Type
NADH T21 1.31x31 TM1 Van der Waals
NADH K77 2.60x60 TM2 polar (hydrogen bond)
NADH D81 2.64x64 TM2 Van der Waals
NADH N90 3.21x21 TM3 Van der Waals
NADH V93 3.24x24 TM3 Van der Waals
NADH C94 3.25x25 TM3 Van der Waals
NADH A98 3.29x29 TM3 Van der Waals
NADH V99 3.30x30 TM3 hydrophobic
NADH Y102 3.33x33 TM3 hydrophobic
NADH Y102 3.33x33 TM3 polar (hydrogen bond)
NADH Y106 3.37x37 TM3 Van der Waals
NADH A153 4.57x57 TM4 hydrophobic
NADH N156 4.60x60 TM4 polar (hydrogen bond)
NADH K171 ECL2 polar (charge-charge)
NADH K171 ECL2 polar (hydrogen bond)
NADH C172 45.50x50 ECL2 Van der Waals
NADH K176 ECL2 polar (hydrogen bond)
NADH H184 5.36x36 TM5 polar (hydrogen bond)
NADH N188 5.40x40 TM5 polar (hydrogen bond)
NADH F191 5.43x43 TM5 hydrophobic
NADH R253 6.55x55 TM6 polar (hydrogen bond)
NADH R253 6.55x55 TM6 polar (charge-charge)
NADH Y256 6.58x58 TM6 polar (hydrogen bond)
NADH Q260 6.62x62 TM6 polar (hydrogen bond)
NADH R274 7.32x31 TM7 Van der Waals
NADH K277 7.35x34 TM7 polar (hydrogen bond)
NADH K277 7.35x34 TM7 polar (charge-charge)
NADH E278 7.36x35 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 P S S ICL1ECL1 L G P ECL1ICL2 P L W T S F I Q ICL2ECL2 N Q S V R E V T Q I K C I E L K S ECL2ICL3 L K S ICL3ECL3 A H Y ECL3N-term M I N S T S T Q P P D E S C S Q N N-termC-term L H I P L K A Q N D L D I S R I K R G N T T L E S T D T L C-term L L I T Q Q I I P V L Y C M V F I A G I L L N G V S G W I F F Y V K S F I I Y L K N I V I A D F V M S L T F P F K I L G D S G W Q L N V F V C R V S A V L F Y V N M Y V S I V F F G L I S F D R Y Y K I V K S V S Y S K L L S V I V W M L M L L L A V P N I I L T E L G R K W H K A S N Y I F V A I F W I V F L L L I V F Y T A I T K K I F K S H S R N S T S V K K K S S R N I F S I V F V F F V C F V P Y H I A R I P Y T K S Q T E S C Q S K E I L R Y M K E F T L L L S A A N V C L D P I I Y F F L C Q P L C K F R E I K
Helix box plot — Download: PNG | SVG G N L L I G A I F V M C Y L V P I I Q Q 1 K N I V I A D F V M S L T F P F K I L G 2 L G F F V I S V Y M N V Y F L V A S V R 3 S K L L S V I V W M L M L L L A V P N I 4 Y F V I L L L F V I W F I A V F I Y N S 5 I F S I V F V F V F C F V P Y H I A R I P 6 I P D L C V N A A S L L L T F E K M Y 7

GPCRdb(A)
GPCRdb(A)
P2Y14 receptor
TM1
1x31 1.31x31 T21
TM2
2x60 2.60x60 K77
2x64 2.64x64 D81
TM3
3x21 3.21x21 N90
3x24 3.24x24 V93
3x25 3.25x25 C94
3x29 3.29x29 A98
3x30 3.30x30 V99
3x33 3.33x33 Y102
3x37 3.37x37 Y106
TM4
4x57 4.57x57 A153
4x60 4.60x60 N156
ECL2
45x50 45.50x50 C172
TM5
5x36 5.36x36 H184
5x40 5.40x40 N188
5x43 5.43x43 F191
TM6
6x55 6.55x55 R253
6x58 6.58x58 Y256
6x62 6.62x62 Q260
TM7
7x31 7.32x31 R274
7x34 7.35x34 K277
7x35 7.36x35 E278