| Ligand | Amino Acid | Generic Number | Segment | Interaction Type |
|---|---|---|---|---|
| 5-MeOT | D155 | 3.32x32 | TM3 | polar (hydrogen bond with backbone) |
| 5-MeOT | D155 | 3.32x32 | TM3 | polar (charge-assisted hydrogen bond) |
| 5-MeOT | V156 | 3.33x33 | TM3 | polar (hydrogen bond) |
| 5-MeOT | S159 | 3.36x36 | TM3 | polar (hydrogen bond) |
| 5-MeOT | T160 | 3.37x37 | TM3 | polar (hydrogen bond) |
| 5-MeOT | T160 | 3.37x37 | TM3 | polar (hydrogen bond) |
| 5-MeOT | L229 | 45.52x52 | ECL2 | polar (hydrogen bond) |
| 5-MeOT | F234 | 5.38x39 | TM5 | hydrophobic |
| 5-MeOT | F234 | 5.38x39 | TM5 | Van der Waals |
| 5-MeOT | V235 | 5.39x40 | TM5 | polar (hydrogen bond) |
| 5-MeOT | G238 | 5.42x43 | TM5 | Van der Waals |
| 5-MeOT | S239 | 5.43x44 | TM5 | Van der Waals |
| 5-MeOT | S242 | 5.46x461 | TM5 | polar (hydrogen bond) |
| 5-MeOT | W336 | 6.48x48 | TM6 | Van der Waals |
| 5-MeOT | F339 | 6.51x51 | TM6 | Van der Waals |
| 5-MeOT | F339 | 6.51x51 | TM6 | hydrophobic |
| 5-MeOT | F340 | 6.52x52 | TM6 | aromatic (edge-to-face) |
| 5-MeOT | F340 | 6.52x52 | TM6 | polar (hydrogen bond) |
| 5-MeOT | N343 | 6.55x55 | TM6 | polar (hydrogen bond) |
| 5-MeOT | N343 | 6.55x55 | TM6 | polar (hydrogen bond) |
| 5-MeOT | V366 | 7.39x38 | TM7 | polar (hydrogen bond) |
| 5-MeOT | Y370 | 7.43x42 | TM7 | Van der Waals |
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|
GPCRdb(A)
|
GPCRdb(A)
|
5-HT2A receptor
|
|---|---|---|
| TM3 | ||
| 3x32 | 3.32x32 | D155 |
| 3x33 | 3.33x33 | V156 |
| 3x36 | 3.36x36 | S159 |
| 3x37 | 3.37x37 | T160 |
| ECL2 | ||
| 45x52 | 45.52x52 | L229 |
| TM5 | ||
| 5x39 | 5.38x39 | F234 |
| 5x40 | 5.39x40 | V235 |
| 5x43 | 5.42x43 | G238 |
| 5x44 | 5.43x44 | S239 |
| 5x461 | 5.46x461 | S242 |
| TM6 | ||
| 6x48 | 6.48x48 | W336 |
| 6x51 | 6.51x51 | F339 |
| 6x52 | 6.52x52 | F340 |
| 6x55 | 6.55x55 | N343 |
| TM7 | ||
| 7x38 | 7.39x38 | V366 |
| 7x42 | 7.43x42 | Y370 |