| Ligand | Amino Acid | Generic Number | Segment | Interaction Type |
|---|---|---|---|---|
| Lysophosphatidylcholine (LPC) | Y55 | 2.42x42 | TM2 | polar (hydrogen bond) |
| Lysophosphatidylcholine (LPC) | Y55 | 2.42x42 | TM2 | polar (hydrogen bond) |
| Lysophosphatidylcholine (LPC) | A106 | 3.41x41 | TM3 | Van der Waals |
| Lysophosphatidylcholine (LPC) | A106 | 3.41x41 | TM3 | hydrophobic |
| Lysophosphatidylcholine (LPC) | C109 | 3.44x44 | TM3 | Van der Waals |
| Lysophosphatidylcholine (LPC) | C110 | 3.45x45 | TM3 | polar (hydrogen bond) |
| Lysophosphatidylcholine (LPC) | V113 | 3.48x48 | TM3 | polar (hydrogen bond) |
| Lysophosphatidylcholine (LPC) | D114 | 3.49x49 | TM3 | Van der Waals |
| Lysophosphatidylcholine (LPC) | L117 | 3.52x52 | TM3 | Van der Waals |
| Lysophosphatidylcholine (LPC) | L128 | ICL2 | Van der Waals | |
| Lysophosphatidylcholine (LPC) | L128 | ICL2 | polar (hydrogen bond with backbone) | |
| Lysophosphatidylcholine (LPC) | V137 | 4.45x45 | TM4 | polar (hydrogen bond) |
| Lysophosphatidylcholine (LPC) | T144 | 4.52x52 | TM4 | Van der Waals |
| Lysophosphatidylcholine (LPC) | E145 | 4.53x53 | TM4 | polar (charge-assisted hydrogen bond) |
| Lysophosphatidylcholine (LPC) | V188 | 5.45x46 | TM5 | Van der Waals |
| Lysophosphatidylcholine (LPC) | V188 | 5.45x46 | TM5 | polar (hydrogen bond with backbone) |
| Lysophosphatidylcholine (LPC) | G189 | 5.46x461 | TM5 | Van der Waals |
| Lysophosphatidylcholine (LPC) | G189 | 5.46x461 | TM5 | polar (hydrogen bond with backbone) |
| Lysophosphatidylcholine (LPC) | F192 | 5.49x49 | TM5 | Van der Waals |
| Lysophosphatidylcholine (LPC) | P193 | 5.50x50 | TM5 | hydrophobic |
| Lysophosphatidylcholine (LPC) | P193 | 5.50x50 | TM5 | Van der Waals |
| Lysophosphatidylcholine (LPC) | L196 | 5.53x53 | TM5 | polar (hydrogen bond) |
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|
GPCRdb(A)
|
GPCRdb(A)
|
GPR4
|
|---|---|---|
| TM2 | ||
| 2x42 | 2.42x42 | Y55 |
| TM3 | ||
| 3x41 | 3.41x41 | A106 |
| 3x44 | 3.44x44 | C109 |
| 3x45 | 3.45x45 | C110 |
| 3x48 | 3.48x48 | V113 |
| 3x49 | 3.49x49 | D114 |
| 3x52 | 3.52x52 | L117 |
| TM4 | ||
| 4x45 | 4.45x45 | V137 |
| 4x52 | 4.52x52 | T144 |
| 4x53 | 4.53x53 | E145 |
| TM5 | ||
| 5x46 | 5.45x46 | V188 |
| 5x461 | 5.46x461 | G189 |
| 5x49 | 5.49x49 | F192 |
| 5x50 | 5.50x50 | P193 |
| 5x53 | 5.53x53 | L196 |