PDB
9JEA
Resolution
3.4 Å
Released
July 9, 2025
Receptor
M1
Class
A
Species
Homo sapiens
Ligand
CHEMBL1379091
Function
Antagonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL1379091 D105 3.32x32 TM3 polar (charge-assisted hydrogen bond)
CHEMBL1379091 Y106 3.33x33 TM3 hydrophobic
CHEMBL1379091 Y106 3.33x33 TM3 Van der Waals
CHEMBL1379091 S109 3.36x36 TM3 Van der Waals
CHEMBL1379091 N110 3.37x37 TM3 Van der Waals
CHEMBL1379091 A193 5.43x44 TM5 Van der Waals
CHEMBL1379091 A193 5.43x44 TM5 hydrophobic
CHEMBL1379091 A196 5.46x461 TM5 hydrophobic
CHEMBL1379091 A196 5.46x461 TM5 Van der Waals
CHEMBL1379091 W387 6.48x48 TM6 Van der Waals
CHEMBL1379091 W387 6.48x48 TM6 aromatic (edge-to-face)
CHEMBL1379091 Y390 6.51x51 TM6 hydrophobic
CHEMBL1379091 Y390 6.51x51 TM6 Van der Waals
CHEMBL1379091 N391 6.52x52 TM6 Van der Waals
CHEMBL1379091 N391 6.52x52 TM6 polar (hydrogen bond)
CHEMBL1379091 Y413 7.39x38 TM7 hydrophobic
CHEMBL1379091 Y413 7.39x38 TM7 Van der Waals
CHEMBL1379091 C416 7.42x41 TM7 hydrophobic
CHEMBL1379091 C416 7.42x41 TM7 Van der Waals
CHEMBL1379091 Y417 7.43x42 TM7 hydrophobic
CHEMBL1379091 Y417 7.43x42 TM7 Van der Waals

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ICL1 T E L K ICL1ECL1 H W A L ECL1ICL2 P L S Y R A K R ICL2ECL2 E R T V L A G Q C Y I Q F L S ECL2ICL3 Q G S E T P G K G G G S S S S S E R S Q P G A E G S P E T P P G R C C R C C R A P R L L Q A Y S W K E E E E E D E G S M E S L T S S E G E E P G S E V V I K M P M V D P E A Q A P T K Q P P R S S P N T V K R P T K K G R D R A G K G Q K P R G K E Q L A K R K ICL3ECL3 K D C V ECL3N-term M N T S A P P A V S P N I T V L A P G K N-termC-term R W D K R R W R K I P K R P G S V H R T P S R Q C C-term G P W Q V A F I G I T T G L L S L A T V T G N L L V L I S F K V N T V N N Y F L L S L A C A D L I I G T F S M N L Y T T Y L L M G G T L A C D L W L A L D Y V A S N A S V M N L L L I S F D R Y F S V T R T P R R A A L M I G L A W L V S F V L W A P A I L F W Q Y L V G Q P I I T F G T A M A A F Y L P V T V M C T L Y W R I Y R E T E N R A R E L A A L T F S L V K E K K A A R T L S A I L L A F I L T W T P Y N I M V L V S T F C P E T L W E L G Y W L C Y V N S T I N P M C Y A L C N K A F R L F R D T L L L C
Helix box plot — Download: PNG | SVG L N G T V T A L S L L G T T I G I F A V 1 L S L A C A D L I I G F T S M N L Y T T Y 2 L L L N M V S A N S A V Y D L A L W L D 3 A A L M I G L A W L V S F V L W A P A I 4 Y L T C M V T V P L Y F A A M A T G F T I 5 S A I L L A F I L T W T P Y N I M V L V 6 M P N I T S N V Y C L W Y G L E W L T 7

GPCRdb(A)
GPCRdb(A)
M1 receptor
TM3
3x32 3.32x32 D105
3x33 3.33x33 Y106
3x36 3.36x36 S109
3x37 3.37x37 N110
TM5
5x44 5.43x44 A193
5x461 5.46x461 A196
TM6
6x48 6.48x48 W378
6x51 6.51x51 Y381
6x52 6.52x52 N382
TM7
7x38 7.39x38 Y404
7x41 7.42x41 C407
7x42 7.43x42 Y408