PDB
9JFY
Resolution
3.2 Å
Released
April 9, 2025
Receptor
NPFF2
Class
A
Species
Homo sapiens
Ligand
Neuropeptide SF
Function
Agonist
Reference
10.1038/S44319-025-00428-2

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Ligand Amino Acid Generic Number Segment Interaction Type
Neuropeptide SF L39 N-term hydrophobic
Neuropeptide SF V129 3.36x36 TM3 hydrophobic
Neuropeptide SF Q185 ECL2 polar (hydrogen bond)
Neuropeptide SF E187 ECL2 polar (charge-assisted hydrogen bond)
Neuropeptide SF Y190 ECL2 aromatic (face-to-edge)
Neuropeptide SF Y190 ECL2 Van der Waals
Neuropeptide SF V203 ECL2 Van der Waals
Neuropeptide SF V203 ECL2 hydrophobic
Neuropeptide SF W205 ECL2 Van der Waals
Neuropeptide SF W205 ECL2 hydrophobic
Neuropeptide SF R207 45.51x51 ECL2 Van der Waals
Neuropeptide SF E208 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
Neuropeptide SF R216 5.35x36 TM5 Van der Waals
Neuropeptide SF Y219 5.38x39 TM5 Van der Waals
Neuropeptide SF T220 5.39x40 TM5 polar (hydrogen bond)
Neuropeptide SF T220 5.39x40 TM5 Van der Waals
Neuropeptide SF L223 5.42x43 TM5 Van der Waals
Neuropeptide SF W291 6.52x52 TM6 hydrophobic
Neuropeptide SF W291 6.52x52 TM6 Van der Waals
Neuropeptide SF M294 6.55x55 TM6 polar (hydrogen bond)
Neuropeptide SF L307 ECL3 hydrophobic
Neuropeptide SF L307 ECL3 Van der Waals
Neuropeptide SF Q308 7.28x27 TM7 Van der Waals
Neuropeptide SF N311 7.31x30 TM7 Van der Waals
Neuropeptide SF N311 7.31x30 TM7 polar (hydrogen bond)
Neuropeptide SF I312 7.32x31 TM7 Van der Waals
Neuropeptide SF I312 7.32x31 TM7 hydrophobic
Neuropeptide SF Y315 7.35x34 TM7 hydrophobic
Neuropeptide SF Y315 7.35x34 TM7 Van der Waals
Neuropeptide SF H319 7.39x38 TM7 polar (hydrogen bond)
Neuropeptide SF F323 7.43x42 TM7 Van der Waals

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ICL1 K H M H ICL1ECL1 G W P F ECL1ICL2 P F K P K L ICL2ECL2 H V Q E E K Y Y R V R L N S Q N K T S P V Y W C R E D W P N Q ECL2ICL3 G R K N Q E Q W ICL3ECL3 D L S P N E L ECL3N-term M N S F F G T P A A S W C L L E S D V S S A P D K E A G R E R R A L S V Q Q R G G P A W S G S L E W S R Q S A G D R R R L G L S R Q T A K S S W S R S R D R T C C C R R A W W I L V P A A D R A R R E R F I M N E K W D T N S S E N W H P I W N V N D T K H H L Y S D I N I T Y V N Y Y L H Q P Q V N-termC-term Q K R A K P M E A Y A L K A K S H V L I N T S N Q L V Q E S T F Q N P H G E T L L Y R K S A E K P Q Q E L V M E E L K E T T N S S E I C-term A A I F I I S Y F L I F F L C M M G N T V V C F I V M R N T V T N L F I L N L A I S D L L V G I F C M P I T L L D N I I A G N T M C K I S G L V Q G I S V A A S V F T L V A I A V D R F Q C V V Y T I K T A F V I I M I I W V L A I T I M S P S A V M L E M R K I Y T T V L F A N I Y L A P L S L I V I M Y G R I G I S L F R A A V P H T H V V S R K K Q K I I K M L L I V A L L F I L S W L P L W T L M M L S D Y A Q I I N I Y I Y P F A H W L A F G N S S V N P I I Y G F F N E N F Q E Q L C F R R G A F Q L
Helix box plot — Download: PNG | SVG T N G M M C L F F I L F Y S I I F I A A 1 L N L A I S D L L V G F I C M P I T L L D 2 A V L T F V S A A V S I G Q V L G S I K 3 A F V I I M I I W V L A I T I M S P S 4 Y M I V I L S L P A L Y I N A F L V T T Y 5 L I V A L L F I L S W L P L W T L M M L 6 I P N V S S N G F A L W H A F P Y I Y 7

GPCRdb(A)
GPCRdb(A)
NPFF2 receptor
TM3
3x36 3.36x36 V231
ECL2
45x51 45.51x51 R309
45x52 45.52x52 E310
TM5
5x36 5.35x36 R318
5x39 5.38x39 Y321
5x40 5.39x40 T322
5x43 5.42x43 L325
TM6
6x52 6.52x52 W393
6x55 6.55x55 M396
TM7
7x27 7.28x27 Q410
7x30 7.31x30 N413
7x31 7.32x31 I414
7x34 7.35x34 Y417
7x38 7.39x38 H421
7x42 7.43x42 F425