PDB
9JID
Resolution
2.8 Å
Released
Dec. 17, 2025
Receptor
HCA3
Class
A
Species
Homo sapiens
Ligand
Function
nicotinic acid
Agonist
Reference
10.1016/J.CELREP.2024.114895

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Ligand Amino Acid Generic Number Segment Interaction Type
nicotinic acid Y86 ECL1 polar (hydrogen bond)
nicotinic acid L104 3.29x29 TM3 hydrophobic
nicotinic acid F107 3.32x32 TM3 hydrophobic
nicotinic acid R111 3.36x36 TM3 polar (hydrogen bond)
nicotinic acid R111 3.36x36 TM3 polar (charge-charge)
nicotinic acid Y284 7.43x42 TM7 polar (hydrogen bond)

NGL is a WebGL based 3D viewer powered by MMTF.

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Snake plot — Download: PNG | SVG
ICL1 L K S W ICL1ECL1 R S D W K F ECL1ICL2 P H H A L N K I ICL2ECL2 L L I Q N G T A N V C I S F S I C H T F ECL2ICL3 Q M D R H A ICL3ECL3 G T Q N C E ECL3N-term M N R H H L Q D H F L E I D K K N C C V F R N-termC-term R C L Q R K I T G E P D N N R S T S V E L T G D P N K T R G A P E A L I A N S G E P W S P S Y L G P T S N N H S K K G H C H Q E P A S L E K Q L G C C I E C-term D D F I A K V L P P V L G L E F I F G L L G N G L A L W I F C F H K S S R I F L F N L A V A D F L L I I C L P F V M D Y Y V R G D I P C R L V L F M F A M N R Q G S I I F L T V V A V D R Y F R V V H S N W T A A I I S C L L W G I T V G L T V H L L K K K R W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R K I K R A I T F I M V V A I V F V I C F L P S V V V R I H I F W L L H T S V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F S T F P N F L I N
Helix box plot — Download: PNG | SVG G N G L L G F I F E L G L V P P L V K A 1 F N L A V A D F L L I I C L P F V M D Y 2 V T L F I I S G Q R N M A F M F L V L R 3 A A I I S C L L W G I T V G L T V H L L 4 S C F L I I G L P L F F E L L F M A E H W 5 M V V A I V F V I C F L P S V V V R I H 6 V P D L M S N M Y T F S L T I F F A L 7

GPCRdb(A)
GPCRdb(A)
HCA3 receptor
TM3
3x29 3.29x29 L104
3x32 3.32x32 F107
3x36 3.36x36 R111
TM7
7x42 7.43x42 Y284