PDB
9JKX
Resolution
3.2 Å
Released
Oct. 29, 2025
Receptor
HCA3
Class
A
Species
Homo sapiens
Ligand
Function
Acifran
Agonist
Reference
10.1371/JOURNAL.PBIO.3003480

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Ligand Amino Acid Generic Number Segment Interaction Type
Acifran V83 2.60x60 TM2 hydrophobic
Acifran L104 3.29x29 TM3 hydrophobic
Acifran F107 3.32x32 TM3 hydrophobic
Acifran R111 3.36x36 TM3 polar (hydrogen bond)
Acifran R111 3.36x36 TM3 polar (charge-charge)
Acifran C177 45.50x50 ECL2 Van der Waals
Acifran S179 45.52x52 ECL2 Van der Waals
Acifran F180 ECL2 hydrophobic
Acifran L280 7.39x38 TM7 Van der Waals
Acifran T283 7.42x41 TM7 Van der Waals
Acifran Y284 7.43x42 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 L K S W ICL1ECL1 R S D W K F ECL1ICL2 P H H A L N K I ICL2ECL2 L L I Q N G T A N V C I S F S I C H T F ECL2ICL3 Q M D R H A ICL3ECL3 G T Q N C E ECL3N-term M N R H H L Q D H F L E I D K K N C C V F R N-termC-term R C L Q R K I T G E P D N N R S T S V E L T G D P N K T R G A P E A L I A N S G E P W S P S Y L G P T S N N H S K K G H C H Q E P A S L E K Q L G C C I E C-term D D F I A K V L P P V L G L E F I F G L L G N G L A L W I F C F H K S S R I F L F N L A V A D F L L I I C L P F V M D Y Y V R G D I P C R L V L F M F A M N R Q G S I I F L T V V A V D R Y F R V V H S N W T A A I I S C L L W G I T V G L T V H L L K K K R W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R K I K R A I T F I M V V A I V F V I C F L P S V V V R I H I F W L L H T S V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F S T F P N F L I N
Helix box plot — Download: PNG | SVG G N G L L G F I F E L G L V P P L V K A 1 F N L A V A D F L L I I C L P F V M D Y 2 V T L F I I S G Q R N M A F M F L V L R 3 A A I I S C L L W G I T V G L T V H L L 4 S C F L I I G L P L F F E L L F M A E H W 5 M V V A I V F V I C F L P S V V V R I H 6 V P D L M S N M Y T F S L T I F F A L 7

GPCRdb(A)
GPCRdb(A)
HCA3 receptor
TM2
2x60 2.60x60 V83
TM3
3x29 3.29x29 L104
3x32 3.32x32 F107
3x36 3.36x36 R111
ECL2
45x50 45.50x50 C177
45x52 45.52x52 S179
TM7
7x38 7.39x38 L280
7x41 7.42x41 T283
7x42 7.43x42 Y284