PDB
9JQY
Resolution
2.9 Å
Released
Oct. 22, 2025
Receptor
EP4
Class
A
Species
Homo sapiens
Ligand
Function
TG6-129
Antagonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
TG6-129 P21 1.39x39 TM1 Van der Waals
TG6-129 M24 1.42x42 TM1 hydrophobic
TG6-129 V69 2.57x57 TM2 hydrophobic
TG6-129 T73 2.61x61 TM2 hydrophobic
TG6-129 Y77 2.65x65 TM2 polar (hydrogen bond)
TG6-129 L96 3.32x32 TM3 Van der Waals
TG6-129 I238 6.46x46 TM6 Van der Waals
TG6-129 C239 6.47x47 TM6 Van der Waals
TG6-129 I270 7.39x38 TM7 Van der Waals
TG6-129 R271 7.40x39 TM7 hydrophobic
TG6-129 R271 7.40x39 TM7 polar (charge-charge)
TG6-129 R271 7.40x39 TM7 polar (hydrogen bond)
TG6-129 I272 7.41x40 TM7 hydrophobic
TG6-129 S274 7.43x42 TM7 Van der Waals
TG6-129 V275 7.44x43 TM7 hydrophobic
TG6-129 L279 7.48x48 TM7 Van der Waals

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ICL1 R K E Q K E ICL1ECL1 G Q W P G ECL1ICL2 A Y F Y S H Y V ICL2ECL2 L G S S R L Q Y P D T W C F I D W T T N ECL2ICL3 S L G T E Q H H A A A A A S V A S R G H P A A S P A L P R L S D F R R R R S F ICL3ECL3 Q P S L E R E V S K ECL3N-term M S T P G V N S S A S L S P D R L N-termC-term L F C R I G G S R R E R S G Q H C S D S Q R T S S A M S G H S R S F I S R E L K E I S S T S Q T L L P D L S L P D L S E N G L G G R N L L P G V P G M G L A Q E D T T S L R T L R I S E T S D S S Q G Q D S E S V L L V D E A G G S G R A G P A P K G S S L Q V T F P S E T L N L S E K C I C-term N S P V T I P A V M F I F G V V G N L V A I V V L C K S T T F Y T L V C G L A V T D L L G T L L V S P V T I A T Y M K G Q P L C E Y S T F I L L F F S L S G L S I I C A M S V E R Y L A I N H D K R L A G L T L F A V Y A S N V L F C A L P N M G V T A H A A Y S Y M Y A G F S S F L I L A T V L C N V L V C G A L L R M H R Q F M R R T R R I A G A E I Q M V I L L I A T S L V V L I C S I P L V V R V F V N Q L Y N P D L Q A I R I A S V N P I L D P W I Y I L L R K T A I E V L S K K I K C
Helix box plot — Download: PNG | SVG L N G V V G F I F M V A P I T V P S N 1 C G L A V T D L L G T L L V S P V T I A 2 A C I I S L G S L S F F L L I F T S Y E 3 A G L T L F A V Y A S N V L F C A L P N 4 N C L V T A L I L F S S F G A Y M Y S Y 5 I A T S L V V L I C S I P L V V R V F V 6 W P D L I P N V S A I R I A Q L D P N 7

GPCRdb(A)
GPCRdb(A)
EP4 receptor
TM1
1x39 1.39x39 P24
1x42 1.42x42 M27
TM2
2x57 2.57x57 V72
2x61 2.61x61 T76
2x65 2.65x65 Y80
TM3
3x32 3.32x32 L99
TM6
6x46 6.46x46 I283
6x47 6.47x47 C284
TM7
7x38 7.39x38 I315
7x39 7.40x39 R316
7x40 7.41x40 I317
7x42 7.43x42 S319
7x43 7.44x43 V320
7x48 7.48x48 L324