PDB
9JQZ
Resolution
2.7 Å
Released
Oct. 22, 2025
Receptor
EP4
Class
A
Species
Homo sapiens
Ligand
grapiprant
Function
Antagonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
grapiprant I20 1.38x38 TM1 hydrophobic
grapiprant M24 1.42x42 TM1 hydrophobic
grapiprant V69 2.57x57 TM2 hydrophobic
grapiprant Y77 2.65x65 TM2 polar (hydrogen bond)
grapiprant Y77 2.65x65 TM2 polar (hydrogen bond)
grapiprant Y77 2.65x65 TM2 Van der Waals
grapiprant L96 3.32x32 TM3 hydrophobic
grapiprant L96 3.32x32 TM3 Van der Waals
grapiprant T165 ECL2 Van der Waals
grapiprant W166 ECL2 hydrophobic
grapiprant W166 ECL2 Van der Waals
grapiprant I270 7.39x38 TM7 hydrophobic
grapiprant I270 7.39x38 TM7 Van der Waals
grapiprant R271 7.40x39 TM7 polar (charge-assisted hydrogen bond)
grapiprant A273 7.42x41 TM7 hydrophobic
grapiprant A273 7.42x41 TM7 Van der Waals
grapiprant S274 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R K E Q K E ICL1ECL1 G Q W P G ECL1ICL2 A Y F Y S H Y V ICL2ECL2 L G S S R L Q Y P D T W C F I D W T T N ECL2ICL3 S L G T E Q H H A A A A A S V A S R G H P A A S P A L P R L S D F R R R R S F ICL3ECL3 Q P S L E R E V S K ECL3N-term M S T P G V N S S A S L S P D R L N-termC-term L F C R I G G S R R E R S G Q H C S D S Q R T S S A M S G H S R S F I S R E L K E I S S T S Q T L L P D L S L P D L S E N G L G G R N L L P G V P G M G L A Q E D T T S L R T L R I S E T S D S S Q G Q D S E S V L L V D E A G G S G R A G P A P K G S S L Q V T F P S E T L N L S E K C I C-term N S P V T I P A V M F I F G V V G N L V A I V V L C K S T T F Y T L V C G L A V T D L L G T L L V S P V T I A T Y M K G Q P L C E Y S T F I L L F F S L S G L S I I C A M S V E R Y L A I N H D K R L A G L T L F A V Y A S N V L F C A L P N M G V T A H A A Y S Y M Y A G F S S F L I L A T V L C N V L V C G A L L R M H R Q F M R R T R R I A G A E I Q M V I L L I A T S L V V L I C S I P L V V R V F V N Q L Y N P D L Q A I R I A S V N P I L D P W I Y I L L R K T A I E V L S K K I K C
Helix box plot — Download: PNG | SVG L N G V V G F I F M V A P I T V P S N 1 C G L A V T D L L G T L L V S P V T I A 2 A C I I S L G S L S F F L L I F T S Y E 3 A G L T L F A V Y A S N V L F C A L P N 4 N C L V T A L I L F S S F G A Y M Y S Y 5 I A T S L V V L I C S I P L V V R V F V 6 W P D L I P N V S A I R I A Q L D P N 7

GPCRdb(A)
GPCRdb(A)
EP4 receptor
TM1
1x38 1.38x38 I23
1x42 1.42x42 M27
TM2
2x57 2.57x57 V72
2x65 2.65x65 Y80
TM3
3x32 3.32x32 L99
TM7
7x38 7.39x38 I315
7x39 7.40x39 R316
7x41 7.42x41 A318
7x42 7.43x42 S319