PDB
9JRO
Resolution
3.5 Å
Released
Oct. 22, 2025
Receptor
EP2
Class
A
Species
Homo sapiens
Ligand
Function
PF-04418948
Antagonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
PF-04418948 I27 1.38x38 TM1 hydrophobic
PF-04418948 S28 1.39x39 TM1 Van der Waals
PF-04418948 M31 1.42x42 TM1 hydrophobic
PF-04418948 T82 2.54x54 TM2 Van der Waals
PF-04418948 I85 2.57x57 TM2 hydrophobic
PF-04418948 S86 2.58x58 TM2 Van der Waals
PF-04418948 V89 2.61x61 TM2 Van der Waals
PF-04418948 Y93 2.65x65 TM2 polar (hydrogen bond)
PF-04418948 F112 3.28x28 TM3 Van der Waals
PF-04418948 T185 ECL2 polar (hydrogen bond)
PF-04418948 W186 ECL2 hydrophobic
PF-04418948 R382 7.40x39 TM7 hydrophobic
PF-04418948 R382 7.40x39 TM7 aromatic (pi-cation)
PF-04418948 S385 7.43x42 TM7 Van der Waals
PF-04418948 I386 7.44x43 TM7 hydrophobic
PF-04418948 S388 7.46x46 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 W R G D V G C S A G R R S S L ICL1ECL1 Q T L V A L A P E ECL1ICL2 P Y F Y Q R R V ICL2ECL2 Y G Q Y V Q Y C P G T W C F I R H G R ECL2ICL3 P S L G S G R G G P G A R R R G E ICL3ECL3 N E T S S R K E K ECL3N-term M G N A S N D S Q S E D C E T R Q W L P P G E N-termC-term R I S L R T Q D A T Q T S C S T Q S D A S K Q A D L C-term S P A I S S V M F S A G V L G N L I A L A L L A R R S L F H V L V T E L V F T D L L G T C L I S P V V L A S Y A R N S R A C T Y F A F A M T F F S L A T M L M L F A M A L E R Y L S I G H S R S G G L A V L P V I Y A V S L L F C S L P L L D T A Y L Q L Y A T L L L L L I V S V L A C N F S V I L N L I R M H R R S R R S R C G R V S M A E E T D H L I L L A I M T I T F A V C S L P F T I F A Y M W D L Q A L R F L S I N S I I D P W V F A I L R P P M R S V L R L V L C C
Helix box plot — Download: PNG | SVG L N G L V G A S F M V S S I A P S 1 T E L V F T D L L G T C L I S P V V L A 2 A F L M L M T A L S F F T M A F A F Y T 3 G L A V L P V I Y A V S L L F C S L P L 4 S F N C A L V S V I L L L L L T A Y L Q 5 A I M T I T F A V C S L P F T I F A Y M 6 W P D I I S N I S L F R L A Q L D W 7

GPCRdb(A)
GPCRdb(A)
EP2 receptor
TM1
1x38 1.38x38 I27
1x39 1.39x39 S28
1x42 1.42x42 M31
TM2
2x54 2.54x54 T82
2x57 2.57x57 I85
2x58 2.58x58 S86
2x61 2.61x61 V89
2x65 2.65x65 Y93
TM3
3x28 3.28x28 F112
TM7
7x39 7.40x39 R302
7x42 7.43x42 S305
7x43 7.44x43 I306
7x46 7.46x46 S308