PDB
9K6L
Resolution
2.8 Å
Released
April 2, 2025
Receptor
TAS2R16
Class
T2
Species
Homo sapiens
Ligand
salicin
Function
Agonist
Reference
10.1016/J.CELREP.2025.115604

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Ligand Amino Acid Generic Number Segment Interaction Type
salicin S63 2.57x57 TM2 polar (hydrogen bond)
salicin S63 2.57x57 TM2 Van der Waals
salicin N66 2.60x60 TM2 Van der Waals
salicin N66 2.60x60 TM2 polar (hydrogen bond)
salicin N67 2.61x61 TM2 Van der Waals
salicin W85 3.32x32 TM3 Van der Waals
salicin W85 3.32x32 TM3 hydrophobic
salicin E86 3.33x33 TM3 Van der Waals
salicin H181 5.43x44 TM5 Van der Waals
salicin I243 6.52x52 TM6 hydrophobic
salicin I243 6.52x52 TM6 Van der Waals
salicin T246 6.55x55 TM6 Van der Waals
salicin I247 6.56x56 TM6 hydrophobic
salicin I247 6.56x56 TM6 Van der Waals
salicin R255 ECL3 polar (charge-assisted hydrogen bond)
salicin E262 7.39x38 TM7 polar (charge-assisted hydrogen bond)
salicin Y266 7.43x42 TM7 polar (hydrogen bond)
salicin Y266 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R L ICL1ECL1 L N Y ECL1ICL2 S F T H H I F L W L R W ICL2ECL2 I Q I Q L L T M E H L P R N S T V T D K L E N F H Q Y ECL2ICL3 C ICL3ECL3 D K ECL3N-term M I N-term P I Q L T V F F M I I Y V L E S L T I I V Q S S L I V A V L G R E W L Q V R M P V D M I L I S L G I S R F C L Q W A S M L N N F C S Y F N V L C N L T I T W E F F N I L T F W L N S L L T V F Y C I K V S R I L R L F P W I L L G S L M I T C V T I I P S A I G N Y Q F Q A H T V A L V I P F I L F L A S T I F L M A S L T K Q I Q H H S T G H N P S M K A R F T A L R S L A V L F I V F T S Y F L T I L I T I I G T L F R C W L W V W E A F V Y A F I L M H S T S L M L S S P T L K G L K R I K C
Helix box plot — Download: PNG | SVG S S Q V I I T L S E L V Y I I M F F V T 1 I S L G I S R F C L Q W A S M L N N F C 2 L S N L W F T L I N F F E W T I T L N C 3 F P W I L L G S L M I T C V T I I P S A 4 T S A L F L I F P I V L A V T H A Q F Q 5 L A V L F I V F T S Y F L T I L I T I I 6 T S H M L I F A Y V F A E W V W L W C 7

GPCRdb(A)
GPCRdb(A)
TAS2R16
TM2
2x57 2.57x57 S63
2x60 2.60x60 N66
2x61 2.61x61 N67
TM3
3x32 3.32x32 W85
3x33 3.33x33 E86
TM5
5x44 5.43x44 H181
TM6
6x52 6.52x52 I243
6x55 6.55x55 T246
6x56 6.56x56 I247
TM7
7x38 7.39x38 E262
7x42 7.43x42 Y266