PDB
9KFI
Resolution
2.9 Å
Released
Aug. 13, 2025
Receptor
RXFP3
Class
A
Species
Homo sapiens
Ligands
Relaxin-3 (chain B)
Relaxin-3 (chain A)
Function
Agonist
Agonist
Reference
10.1038/S42003-025-08220-7
Relaxin-3 (chain B) Relaxin-3 (chain A)

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Ligand Amino Acid Generic Number Segment Interaction Type
Relaxin-3 (chain B) W138 2.60x60 TM2 hydrophobic
Relaxin-3 (chain B) E141 2.63x63 TM2 polar (charge-assisted hydrogen bond)
Relaxin-3 (chain B) D145 ECL1 polar (charge-assisted hydrogen bond)
Relaxin-3 (chain B) F146 ECL1 Van der Waals
Relaxin-3 (chain B) F146 ECL1 polar (hydrogen bond with backbone)
Relaxin-3 (chain B) T162 3.32x32 TM3 Van der Waals
Relaxin-3 (chain A) V241 ECL2 hydrophobic
Relaxin-3 (chain A) M242 ECL2 hydrophobic
Relaxin-3 (chain B) E244 ECL2 polar (charge-assisted hydrogen bond)
Relaxin-3 (chain B) L246 ECL2 hydrophobic
Relaxin-3 (chain B) L246 ECL2 Van der Waals
Relaxin-3 (chain B) C247 45.50x50 ECL2 Van der Waals
Relaxin-3 (chain B) C247 45.50x50 ECL2 polar (hydrogen bond with backbone)
Relaxin-3 (chain B) L248 45.51x51 ECL2 hydrophobic
Relaxin-3 (chain A) L248 45.51x51 ECL2 hydrophobic
Relaxin-3 (chain A) V249 45.52x52 ECL2 polar (hydrogen bond with backbone)
Relaxin-3 (chain B) V249 45.52x52 ECL2 Van der Waals
Relaxin-3 (chain A) V249 45.52x52 ECL2 Van der Waals
Relaxin-3 (chain B) V249 45.52x52 ECL2 hydrophobic
Relaxin-3 (chain A) R250 ECL2 Van der Waals
Relaxin-3 (chain B) W263 ECL2 Van der Waals
Relaxin-3 (chain B) H268 5.39x40 TM5 polar (hydrogen bond)
Relaxin-3 (chain B) H268 5.39x40 TM5 Van der Waals
Relaxin-3 (chain B) K271 5.42x43 TM5 polar (charge-assisted hydrogen bond)
Relaxin-3 (chain B) N342 6.51x51 TM6 Van der Waals
Relaxin-3 (chain B) K353 6.62x62 TM6 Van der Waals
Relaxin-3 (chain B) F364 7.28x27 TM7 aromatic (face-to-edge)
Relaxin-3 (chain B) F364 7.28x27 TM7 Van der Waals
Relaxin-3 (chain B) Q367 7.31x30 TM7 polar (hydrogen bond)
Relaxin-3 (chain B) Q367 7.31x30 TM7 polar (hydrogen bond with backbone)
Relaxin-3 (chain B) V368 7.32x31 TM7 hydrophobic
Relaxin-3 (chain B) V368 7.32x31 TM7 Van der Waals
Relaxin-3 (chain B) F371 7.35x34 TM7 hydrophobic
Relaxin-3 (chain B) F371 7.35x34 TM7 Van der Waals
Relaxin-3 (chain B) V375 7.39x38 TM7 hydrophobic
Relaxin-3 (chain B) V375 7.39x38 TM7 Van der Waals
Relaxin-3 (chain B) H379 7.43x42 TM7 Van der Waals

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Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.

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Snake plot — Download: PNG | SVG
ICL1 Q G W R ICL1ECL1 D F K W P F ECL1ICL2 A L K S H R T R G H G R G D C C G R S L G D S ICL2ECL2 T T V K V M G E E L C L V R F P D K L L G R D ECL2ICL3 G G R P ICL3ECL3 A V P F ECL3N-term M Q M A D A A T I A T M N K A A G G D K L A E L F S L V P D L L E A A N T S G N A S L Q L P D L W W E L G L E L P D G A P P G H P P G S G G A E S A D T E N-termC-term R I A S P S I T S M R P F T A T T K P E H E D Q G L Q A P A P P H A A A E P D L L Y Y P P G V V V Y S G G R Y D L L P S S S A Y C-term A R V R I L I S V V Y W V V C A L G L A G N L L V L Y L M K S M K S S I N L F V T N L A L T D F Q F V L T L P F W A V E N A L G K A M C K I V S M V T S M N M Y A S V F F L T A M S V T R Y H S V A S C C F S A K A L C V W I W A L A A L A S L P S A I F S R Q F W L G L Y H S Q K V L L G F V L P L G I I I L C Y L L L V R F I A D R R A A G T K G G A A V A T G A S A R R L S K V T K S V T I V V L S F F L C W L P N Q A L T T W S I L I K F N S Q E Y F L C Q V Y A F P V S V C L A H S N S C L N P V L Y C L V R R E L K S F R K A L L W
Helix box plot — Download: PNG | SVG L N G A L G L A C V V W Y V V S I L I R 1 T N L A L T D F Q F V L T L P F W A V E 2 A T L F F V S A Y M N M S T V M S V I K 3 A K A L C V W I W A L A A L A S L P S 4 Y C L I I I G L P L V F G L L V K Q S H Y 5 T I V V L S F F L C W L P N Q A L T T W 6 V P N L C S N S H A L C V S V P F A Y 7

GPCRdb(A)
GPCRdb(A)
RXFP3
TM2
2x60 2.60x60 W138
2x63 2.63x63 E141
TM3
3x32 3.32x32 T162
ECL2
45x50 45.50x50 C247
45x51 45.51x51 L248
45x52 45.52x52 V249
TM5
5x40 5.39x40 H268
5x43 5.42x43 K271
TM6
6x51 6.51x51 N342
6x62 6.62x62 K353
TM7
7x27 7.28x27 F364
7x30 7.31x30 Q367
7x31 7.32x31 V368
7x34 7.35x34 F371
7x38 7.39x38 V375
7x42 7.43x42 H379