PDB
9KV8
Resolution
3.2 Å
Released
Nov. 26, 2025
Receptor
C3a
Class
A
Species
Mus musculus
Ligand
TLQP-21 (Human)
Function
Agonist
Reference
10.1101/2025.05.26.656101

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Ligand Amino Acid Generic Number Segment Interaction Type
TLQP-21 (Human) H81 2.63x63 TM2 polar (hydrogen bond)
TLQP-21 (Human) H81 2.63x63 TM2 Van der Waals
TLQP-21 (Human) W88 23.50x50 ECL1 hydrophobic
TLQP-21 (Human) P99 3.29x29 TM3 Van der Waals
TLQP-21 (Human) I102 3.32x32 TM3 hydrophobic
TLQP-21 (Human) I102 3.32x32 TM3 Van der Waals
TLQP-21 (Human) I103 3.33x33 TM3 Van der Waals
TLQP-21 (Human) I103 3.33x33 TM3 hydrophobic
TLQP-21 (Human) I165 ECL2 Van der Waals
TLQP-21 (Human) I171 ECL2 hydrophobic
TLQP-21 (Human) I171 ECL2 Van der Waals
TLQP-21 (Human) Y174 45.52x52 ECL2 Van der Waals
TLQP-21 (Human) R333 5.42x43 TM5 polar (charge-assisted hydrogen bond)
TLQP-21 (Human) Y386 6.51x51 TM6 polar (hydrogen bond)
TLQP-21 (Human) Y386 6.51x51 TM6 Van der Waals
TLQP-21 (Human) V389 6.54x54 TM6 Van der Waals
TLQP-21 (Human) M407 7.32x31 TM7 Van der Waals
TLQP-21 (Human) M407 7.32x31 TM7 hydrophobic
TLQP-21 (Human) D410 7.35x34 TM7 polar (charge-assisted hydrogen bond)
TLQP-21 (Human) I414 7.39x38 TM7 Van der Waals
TLQP-21 (Human) I414 7.39x38 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 M K T ICL1ECL1 G H W P Y ECL1ICL2 P I W C Q N H R ICL2ECL2 D L F I M D N R S I C R Y N F D S S R S Y D Y W D Y V Y K L S L P E S N S T D N S T A Q L T G H M N D R S A P S S V Q A R D Y F W T V T T A L Q S Q P F L T S P E D S F S L D S A N Q Q P H Y G G K P P N V L T A A V P S G F P V E D R K S N T L N A D A F L S A H T E L F P T A S S G H L Y P Y D F Q G D Y V D Q F T Y D N H ECL2ICL3 T N F T K S R ICL3ECL3 D P E ECL3N-term M E S F D A D T N S T D L H S R P L F N-termC-term S I K G I L E A A F S E E L T H S T N C T Q D K A S S K R N N M S T D V C-term Q P Q D I A S M V I L G L T C L L G L L G N G L V L W V A G V K T V N T V W F L H L T L A D F L C C L S L P F S L A H L I L Q G L F L C K L I P S I I I L N M F A S V F L L T A I S L D R C L I V H K N V R T A F A I C G C V W V V A F V M C V P V F V Y R V P T P L M A I T I T R L V V G F L V P F F I M V I C Y S L I V F R M R K N K T F R V A V A V V T V F F I C W T P Y H L V G V L L L I T S S L G E A V M S W D H M S I A L A S A N S C F N P F L Y A L L G K D A R Q F R K K
Helix box plot — Download: PNG | SVG G N G L L G L L C T L G L I V M S A I D 1 L H L T L A D F L C C L S L P F S L A H 2 A T L L F V S A F M N L I I I S P I L K 3 A F A I C G C V W V V A F V M C V P V 4 Y C I V M I F F P V L F G V V L R T I T I 5 V A V V T V F F I C W T P Y H L V G V L 6 F P N F C S N A S A L A I S M H D W S 7

GPCRdb(A)
GPCRdb(A)
C3a receptor
TM2
2x63 2.63x63 H81
ECL1
23x50 23.50x50 W88
TM3
3x29 3.29x29 P99
3x32 3.32x32 I102
3x33 3.33x33 I103
ECL2
45x52 45.52x52 Y174
TM5
5x43 5.42x43 R333
TM6
6x51 6.51x51 Y386
6x54 6.54x54 V389
TM7
7x31 7.32x31 M407
7x34 7.35x34 D410
7x38 7.39x38 I414