PDB
9KVS
Resolution
2.8 Å
Released
June 10, 2026
Receptor
C3a
Class
A
Species
Homo sapiens
Ligand
SB290157
Function
Antagonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
SB290157 H81 2.63x63 TM2 aromatic (face-to-edge)
SB290157 L82 2.64x64 TM2 hydrophobic
SB290157 I98 3.28x28 TM3 hydrophobic
SB290157 P99 3.29x29 TM3 hydrophobic
SB290157 I102 3.32x32 TM3 hydrophobic
SB290157 V103 3.33x33 TM3 hydrophobic
SB290157 Y174 45.52x52 ECL2 polar (hydrogen bond)
SB290157 Y174 45.52x52 ECL2 Van der Waals
SB290157 R340 5.42x43 TM5 polar (charge-assisted hydrogen bond)
SB290157 Y393 6.51x51 TM6 Van der Waals
SB290157 Y393 6.51x51 TM6 polar (hydrogen bond with backbone)
SB290157 F396 6.54x54 TM6 Van der Waals
SB290157 G397 6.55x55 TM6 polar (hydrogen bond with backbone)
SB290157 G397 6.55x55 TM6 Van der Waals
SB290157 D417 7.35x34 TM7 polar (charge-assisted hydrogen bond)
SB290157 H418 7.36x35 TM7 Van der Waals
SB290157 I421 7.39x38 TM7 Van der Waals
SB290157 I421 7.39x38 TM7 hydrophobic

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ICL1 M Q R ICL1ECL1 G Q W P Y ECL1ICL2 P I W C Q N H R ICL2ECL2 E I F T T D N H N R C G Y K F G L S S S L D Y P D F Y G D P L E N R S L E N I V Q P P G E M N D R L D P S S F Q T N D H P W T V P T V F Q P Q T F Q R P S A D S L P R G S A R L T S Q N L Y S N V F K P A D V V S P K I P S G F P I E D H E T S P L D N S D A F L S T H L K L F P S A S S N S F Y E S E L P Q G F Q D Y Y N L G Q F T D D D Q ECL2ICL3 G R F A K S Q ICL3ECL3 D P E ECL3N-term M A S F S A E T N S T D L L S Q P W N N-termC-term S I Q G I L E A A F S E E L T R S T H C P S N N V I S E R N S T T V C-term E P P V I L S M V I L S L T F L L G L P G N G L V L W V A G L K T V N T I W F L H L T L A D L L C C L S L P F S L A H L A L Q G R F L C K L I P S I I V L N M F A S V F L L T A I S L D R C L V V F K N V G M A C S I C G C I W V V A F V M C I P V F V Y R V P T P L V A I T I T R L V V G F L L P S V I M I A C Y S F I V F R M Q R S K T F R V A V V V V A V F L V C W T P Y H I F G V L S L L T T P L G K T L M S W D H V C I A L A S A N S C F N P F L Y A L L G K D A R Q F R K K
Helix box plot — Download: PNG | SVG G N G P L G L L F T L S L I V M S L I V 1 L H L T L A D L L C C L S L P F S L A H 2 A T L L F V S A F M N L V I I S P I L K 3 A C S I C G C I W V V A F V M C I P V 4 Y C A I M I V S P L L F G V V L R T I T I 5 V V V V A V F L V C W T P Y H I F G V L 6 F P N F C S N A S A L A I C V H D W S 7

GPCRdb(A)
GPCRdb(A)
C3a receptor
TM2
2x63 2.63x63 H81
2x64 2.64x64 L82
TM3
3x28 3.28x28 I98
3x29 3.29x29 P99
3x32 3.32x32 I102
3x33 3.33x33 V103
ECL2
45x52 45.52x52 Y174
TM5
5x43 5.42x43 R340
TM6
6x51 6.51x51 Y393
6x54 6.54x54 F396
6x55 6.55x55 G397
TM7
7x34 7.35x34 D417
7x35 7.36x35 H418
7x38 7.39x38 I421