PDB
9KXS
Resolution
3.3 Å
Released
Nov. 26, 2025
Receptor
C5a1
Class
A
Species
Mus musculus
Ligand
EP67
Function
Agonist
Reference
10.1073/PNAS.2614459123

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Ligand Amino Acid Generic Number Segment Interaction Type
EP67 L92 2.60x60 TM2 hydrophobic
EP67 P113 3.29x29 TM3 hydrophobic
EP67 I116 3.32x32 TM3 hydrophobic
EP67 Y178 ECL2 hydrophobic
EP67 I186 45.52x52 ECL2 polar (hydrogen bond with backbone)
EP67 I186 45.52x52 ECL2 Van der Waals
EP67 N187 ECL2 Van der Waals
EP67 Y188 ECL2 polar (hydrogen bond with backbone)
EP67 Y188 ECL2 Van der Waals
EP67 G189 ECL2 Van der Waals
EP67 Y259 6.51x51 TM6 polar (hydrogen bond)
EP67 T262 6.54x54 TM6 Van der Waals
EP67 G263 6.55x55 TM6 Van der Waals
EP67 N283 7.35x34 TM7 polar (hydrogen bond)
EP67 N283 7.35x34 TM7 Van der Waals
EP67 C286 7.38x37 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 A R R ICL1ECL1 N Y W Y F ECL1ICL2 P I W C Q K V R ICL2ECL2 E A Y K D F Y S E H T V C G I N Y G G G ECL2ICL3 K A T R S ICL3ECL3 P P S ECL3N-term M D P I D N S S F E I N Y D H Y G T M D P N I P A D G I H L P K R N-termC-term L P S I I R N A L S E D S V G R D S K T F T P S T T D T S T R K S Q A V C-term Q P G D V A A L I I Y S V V F L V G V P G N A L V V W V T A F E A V N A I W F L N L A V A D L L S C L A L P V L F T T V L N H D A T A C I V L P S L I L L N M Y A S I L L L A T I S A D R F L L V F K G T G L A W M A C G V A W V L A L L L T I P S F V Y R S F P K E K A V A I L R L M V G F V L P L L T L N I C Y T F L L L R T W S R T K T L K V V M A V V I C F F I F W L P Y Q V T G V M I A W L S P T L K R V E K L N S L C V S L A Y I N C C V N P I I Y V M A G Q G F L R S H G R L
Helix box plot — Download: PNG | SVG A N G P V G V L F V V S Y I I L A A V D 1 L N L A V A D L L S C L A L P V L F T T 2 T A L L L I S A Y M N L L I L S P L V I 3 A W M A C G V A W V L A L L L T I P S 4 Y C I N L T L L P L V F G V M L R L I A V 5 M A V V I C F F I F W L P Y Q V T G V M 6 I P N V C C N I Y A L S V C L S N L K 7

GPCRdb(A)
GPCRdb(A)
C5a1 receptor
TM2
2x60 2.60x60 L92
TM3
3x29 3.29x29 P113
3x32 3.32x32 I116
ECL2
45x52 45.52x52 I190
TM6
6x51 6.51x51 Y259
6x54 6.54x54 T262
6x55 6.55x55 G263
TM7
7x34 7.35x34 N283
7x37 7.38x37 C286