PDB
9L3Z
Resolution
3.9 Å
Released
March 12, 2025
Receptor
chemerin
Class
A
Species
Homo sapiens
Ligand
LRH7-C2
Function
Antagonist
Reference
10.1093/PROCEL/PWAE073

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Ligand Amino Acid Generic Number Segment Interaction Type
LRH7-C2 Y390 6.51x51 TM6 hydrophobic
LRH7-C2 N394 6.55x55 TM6 polar (hydrogen bond)
LRH7-C2 G411 ECL3 polar (hydrogen bond with backbone)
LRH7-C2 G411 ECL3 Van der Waals
LRH7-C2 L412 7.35x34 TM7 hydrophobic
LRH7-C2 L412 7.35x34 TM7 Van der Waals
LRH7-C2 A415 7.38x37 TM7 Van der Waals
LRH7-C2 A415 7.38x37 TM7 hydrophobic
LRH7-C2 T416 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 M K K ICL1ECL1 Y H W V F ECL1ICL2 P V W S Q N H R ICL2ECL2 D T A N L H G K I S C F N N F S L S T P G S S S W P ECL2ICL3 L A K T ICL3ECL3 T A M ECL3N-term M R M E D E D Y N T S I S Y G D E Y P D Y L D S I V V L E D L S N-termC-term S R L V N A L S E D T G H S S Y P S H R S F T K M S S M N E R T S M N E R E T G M L C-term P L E A R V T R I F L V V V Y S I V C F L G I L G N G L V I I I A T F K T V N M V W F L N L A V A D F L F N V F L P I H I T Y A A M D G T A M C K I S N F L L I H N M F T S V F L L T I I S S D R C I S V L L S V R L A Y M A C M V I W V L A F F L S S P S L V F R T H S Q M D P V G Y S R H M V V T V T R F L C G F L V P V L I I T A C Y L T I V C K L Q R N R K K P F K I I V T I I I T F F L C W C P Y H T L N L L E L H H P G S V F S L G L P L A T A L A I A N S C M N P I L Y V F M G Q D K V A F K K F L F
Helix box plot — Download: PNG | SVG G N G L I G L F C V I S Y V V V L F I R 1 L N L A V A D F L F N V F L P I H I T Y 2 I T L L F V S T F M N H I L L F N S I K 3 A Y M A C M V I W V L A F F L S S P S 4 Y C A T I I L V P V L F G C L F R T V T V 5 V T I I I T F F L C W C P Y H T L N L L 6 I P N M C S N A I A L A T A L P L G L 7

GPCRdb(A)
GPCRdb(A)
chemerin receptor
TM6
6x51 6.51x51 Y276
6x55 6.55x55 N280
TM7
7x34 7.35x34 L298
7x37 7.38x37 A301
7x38 7.39x38 T302