PDB
9L74
Resolution
3.7 Å
Released
Nov. 26, 2025
Receptor
S1P3
Class
A
Species
Homo sapiens
Ligand
Function
d16:1 S1P
Agonist
Reference
—

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
d16:1 S1P N95 2.60x60 TM2 Van der Waals
d16:1 S1P S99 2.64x64 TM2 polar (hydrogen bond)
d16:1 S1P S99 2.64x64 TM2 polar (hydrogen bond)
d16:1 S1P G100 23.47x47 ECL1 Van der Waals
d16:1 S1P R114 3.28x28 TM3 Van der Waals
d16:1 S1P E115 3.29x29 TM3 polar (charge-charge)
d16:1 S1P M118 3.32x32 TM3 hydrophobic
d16:1 S1P F119 3.33x33 TM3 hydrophobic
d16:1 S1P L122 3.36x36 TM3 hydrophobic
d16:1 S1P L168 4.56x56 TM4 hydrophobic
d16:1 S1P I188 ECL2 Van der Waals
d16:1 S1P L189 ECL2 hydrophobic
d16:1 S1P C200 5.43x43 TM5 Van der Waals
d16:1 S1P I203 5.46x46 TM5 Van der Waals
d16:1 S1P L259 6.51x51 TM6 Van der Waals
d16:1 S1P F260 6.52x52 TM6 hydrophobic
d16:1 S1P F263 6.55x55 TM6 hydrophobic
d16:1 S1P I284 7.39x38 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 N K F H ICL1ECL1 G K K T F S L ECL1ICL2 M R P Y D A N ICL2ECL2 W N C L H N L P D C S T I L P L Y ECL2ICL3 V A ICL3ECL3 R V Q A C ECL3N-term M A T A L P P R L Q P V R G N E T L R E H Y Q Y V G K L A G R L K E A S E G N-termC-term N C L V R G R G A R A S P I Q P A L D P S R S K S S S S N N S S H S P K V K E D L P H T A P S S C I M D K N A A L Q N G I F C N C-term S T L T T V L F L V I C S F I V L E N L M V L I A I W K N N R M Y F F I G N L A L C D L L A G I A Y K V N I L M S S P T V W F L R E G S M F V A L G A S T C S L L A I A I E R H L T M I K K R H R V F L L I G M C W L I A F T L G A L P I L G S K K Y I A F C I S I F T A I L V T I V I L Y A R I Y F L V K S S S R K N H N N S E R S M A L L R T V V I V V S V F I A C W S P L F I L F L I D V A C P I L F K A Q W F I V L A V L N S A M N P V I Y T L A S K E F F R M R R A L V C
Helix box plot — Download: PNG | SVG L N E L V I F S C I V L F L V T T L T S 1 G N L A L C D L L A G I A Y K V N I L M 2 A L L S C T S A G L A V F M S G E R L F 3 V F L L I G M C W L I A F T L G A L P I 4 Y L I V I T V L I A T F I S I C F A I Y 5 V I V V S V F I A C W S P L F I L F L I 6 V P N M A S N L V A L V I F W Q A K F 7

GPCRdb(A)
GPCRdb(A)
S1P3 receptor
TM2
2x60 2.60x60 N95
2x64 2.64x64 S99
ECL1
23x47 23.47x47 G100
TM3
3x28 3.28x28 R114
3x29 3.29x29 E115
3x32 3.32x32 M118
3x33 3.33x33 F119
3x36 3.36x36 L122
TM4
4x56 4.56x56 L168
TM5
5x43 5.43x43 C200
5x46 5.46x46 I203
TM6
6x51 6.51x51 L259
6x52 6.52x52 F260
6x55 6.55x55 F263
TM7
7x38 7.39x38 I284