PDB
9L74
Resolution
3.7 Å
Released
Nov. 26, 2025
Receptor
S1P3
Class
A
Species
Homo sapiens
Ligand
d16:1 S1P
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
d16:1 S1P S99 2.64x64 TM2 polar (hydrogen bond)
d16:1 S1P S99 2.64x64 TM2 polar (hydrogen bond)
d16:1 S1P E115 3.29x29 TM3 Van der Waals
d16:1 S1P M118 3.32x32 TM3 hydrophobic
d16:1 S1P M118 3.32x32 TM3 Van der Waals
d16:1 S1P F119 3.33x33 TM3 hydrophobic
d16:1 S1P F119 3.33x33 TM3 Van der Waals
d16:1 S1P L122 3.36x36 TM3 hydrophobic
d16:1 S1P L122 3.36x36 TM3 Van der Waals
d16:1 S1P I188 ECL2 Van der Waals
d16:1 S1P L189 ECL2 hydrophobic
d16:1 S1P L189 ECL2 Van der Waals
d16:1 S1P L259 6.51x51 TM6 hydrophobic
d16:1 S1P F260 6.52x52 TM6 Van der Waals
d16:1 S1P F260 6.52x52 TM6 hydrophobic
d16:1 S1P F263 6.55x55 TM6 hydrophobic
d16:1 S1P F263 6.55x55 TM6 Van der Waals
d16:1 S1P I284 7.39x38 TM7 Van der Waals

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ICL1 N K F H ICL1ECL1 G K K T F S L ECL1ICL2 M R P Y D A N ICL2ECL2 W N C L H N L P D C S T I L P L Y ECL2ICL3 V A ICL3ECL3 R V Q A C ECL3N-term M A T A L P P R L Q P V R G N E T L R E H Y Q Y V G K L A G R L K E A S E G N-termC-term N C L V R G R G A R A S P I Q P A L D P S R S K S S S S N N S S H S P K V K E D L P H T A P S S C I M D K N A A L Q N G I F C N C-term S T L T T V L F L V I C S F I V L E N L M V L I A I W K N N R M Y F F I G N L A L C D L L A G I A Y K V N I L M S S P T V W F L R E G S M F V A L G A S T C S L L A I A I E R H L T M I K K R H R V F L L I G M C W L I A F T L G A L P I L G S K K Y I A F C I S I F T A I L V T I V I L Y A R I Y F L V K S S S R K N H N N S E R S M A L L R T V V I V V S V F I A C W S P L F I L F L I D V A C P I L F K A Q W F I V L A V L N S A M N P V I Y T L A S K E F F R M R R A L V C
Helix box plot — Download: PNG | SVG L N E L V I F S C I V L F L V T T L T S 1 G N L A L C D L L A G I A Y K V N I L M 2 A L L S C T S A G L A V F M S G E R L F 3 V F L L I G M C W L I A F T L G A L P I 4 Y L I V I T V L I A T F I S I C F A I Y 5 V I V V S V F I A C W S P L F I L F L I 6 V P N M A S N L V A L V I F W Q A K F 7

GPCRdb(A)
GPCRdb(A)
S1P3 receptor
TM2
2x64 2.64x64 S99
TM3
3x29 3.29x29 E115
3x32 3.32x32 M118
3x33 3.33x33 F119
3x36 3.36x36 L122
TM6
6x51 6.51x51 L259
6x52 6.52x52 F260
6x55 6.55x55 F263
TM7
7x38 7.39x38 I284