| Ligand | Amino Acid | Generic Number | Segment | Interaction Type |
|---|---|---|---|---|
| Cholesterol | W70 | 2.52x52 | TM2 | hydrophobic |
| alpha-Hexylcinnamaldehyde | Y71 | 2.53x53 | TM2 | hydrophobic |
| Cholesterol | T73 | 2.55x55 | TM2 | hydrophobic |
| Cholesterol | V74 | 2.56x56 | TM2 | hydrophobic |
| Cholesterol | K78 | 2.60x60 | TM2 | hydrophobic |
| Cholesterol | I90 | ECL1 | Van der Waals | |
| Cholesterol | G94 | 3.24x24 | TM3 | Van der Waals |
| Cholesterol | T97 | 3.27x27 | TM3 | hydrophobic |
| Cholesterol | Q98 | 3.28x28 | TM3 | hydrophobic |
| Cholesterol | F101 | 3.31x31 | TM3 | hydrophobic |
| alpha-Hexylcinnamaldehyde | F102 | 3.32x32 | TM3 | hydrophobic |
| alpha-Hexylcinnamaldehyde | I103 | 3.33x33 | TM3 | hydrophobic |
| alpha-Hexylcinnamaldehyde | G106 | 3.36x36 | TM3 | Van der Waals |
| alpha-Hexylcinnamaldehyde | C107 | 3.37x37 | TM3 | polar (hydrogen bond) |
| alpha-Hexylcinnamaldehyde | F110 | 3.40x40 | TM3 | hydrophobic |
| Cholesterol | W147 | 4.50x50 | TM4 | hydrophobic |
| alpha-Hexylcinnamaldehyde | I153 | 4.56x56 | TM4 | hydrophobic |
| alpha-Hexylcinnamaldehyde | P157 | 4.60x60 | TM4 | hydrophobic |
| alpha-Hexylcinnamaldehyde | I179 | 45.52x52 | ECL2 | hydrophobic |
| alpha-Hexylcinnamaldehyde | D197 | 5.39x39 | TM5 | hydrophobic |
| alpha-Hexylcinnamaldehyde | L200 | 5.42x42 | TM5 | Van der Waals |
| alpha-Hexylcinnamaldehyde | A201 | 5.43x43 | TM5 | hydrophobic |
| alpha-Hexylcinnamaldehyde | T204 | 5.46x46 | TM5 | hydrophobic |
| alpha-Hexylcinnamaldehyde | L205 | 5.47x47 | TM5 | Van der Waals |
| alpha-Hexylcinnamaldehyde | F249 | 6.47x47 | TM6 | hydrophobic |
| alpha-Hexylcinnamaldehyde | C253 | 6.51x51 | TM6 | Van der Waals |
| alpha-Hexylcinnamaldehyde | Y257 | 6.55x55 | TM6 | hydrophobic |
| alpha-Hexylcinnamaldehyde | Y276 | 7.41x40 | TM7 | hydrophobic |
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|
GPCRdb(A)
|
GPCRdb(A)
|
OR6C76
|
|---|---|---|
| TM2 | ||
| 2x52 | 2.52x52 | S69 |
| 2x53 | 2.53x53 | F70 |
| 2x55 | 2.55x55 | S72 |
| 2x56 | 2.56x56 | V73 |
| 2x60 | 2.60x60 | R77 |
| TM3 | ||
| 3x24 | 3.24x24 | A93 |
| 3x27 | 3.27x27 | A96 |
| 3x28 | 3.28x28 | Q97 |
| 3x31 | 3.31x31 | F100 |
| 3x32 | 3.32x32 | F101 |
| 3x33 | 3.33x33 | I102 |
| 3x36 | 3.36x36 | G105 |
| 3x37 | 3.37x37 | S106 |
| 3x40 | 3.40x40 | F109 |
| TM4 | ||
| 4x50 | 4.50x50 | W146 |
| 4x56 | 4.56x56 | V152 |
| 4x60 | 4.60x60 | P156 |
| ECL2 | ||
| 45x52 | 45.52x52 | S178 |
| TM5 | ||
| 5x39 | 5.39x39 | S196 |
| 5x42 | 5.42x42 | L199 |
| 5x43 | 5.43x43 | A200 |
| 5x46 | 5.46x46 | T203 |
| 5x47 | 5.47x47 | L204 |
| TM6 | ||
| 6x47 | 6.47x47 | S248 |
| 6x51 | 6.51x51 | C252 |
| 6x55 | 6.55x55 | Y256 |
| TM7 | ||
| 7x40 | 7.41x40 | N275 |