PDB
9LDX
Resolution
2.8 Å
Released
Jan. 28, 2026
Receptor
OR6C76
Class
O2
Species
Homo sapiens
Ligands
Cholesterol
Benzophenone
Function
PAM
Agonist
Reference
10.1016/J.CELL.2025.12.017
Cholesterol Benzophenone

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Ligand Amino Acid Generic Number Segment Interaction Type
Cholesterol W70 2.52x52 TM2 hydrophobic
Cholesterol V74 2.56x56 TM2 hydrophobic
Cholesterol F101 3.31x31 TM3 hydrophobic
Benzophenone I103 3.33x33 TM3 hydrophobic
Benzophenone C107 3.37x37 TM3 Van der Waals
Benzophenone C107 3.37x37 TM3 polar (hydrogen bond)
Benzophenone I153 4.56x56 TM4 Van der Waals
Benzophenone L200 5.42x42 TM5 hydrophobic
Benzophenone L200 5.42x42 TM5 Van der Waals
Benzophenone Y257 6.55x55 TM6 Van der Waals
Benzophenone Y257 6.55x55 TM6 aromatic (face-to-edge)

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Snake plot — Download: PNG | SVG
ICL1 S H L K ICL1ECL1 D K S I ECL1ICL2 P L H Y T T I M ICL2ECL2 Q L D F C D S N V I D H F T C D S A P L L Q I S C T D ECL2ICL3 I P ICL3ECL3 K T ECL3N-term M K N R T S V T D F I L L G L T D N-termC-term K H C-term N P Q L Q V V I F S F L F L T Y V L S V T G N L T I I S L T L L D T P M Y F F L R N F S L E I S F T S V C N P R F L I S I L T G S Y N A C A A Q L F F F I F L G S T E F F L L A S M S Y D C Y V A I C K S D R I C Y Q L I I S S W L A G F L V I F P P L A M G L T S T L E L M S F I L A L F T L I S T L I L V I L S Y T Y I I R T I L R S A Q Q R K K A F S T C S S H V I V V S I S Y G S C I F M Y V S A K E G V A L T K G V A I L N T S V A P M L N P F I Y T L R N Q Q F K D I S H V K Q A V L R K K K K
Helix box plot — Download: PNG | SVG L N G T V S L V Y T L F L F S F I V V Q 1 R N F S L E I S F T S V C N P R F L I 2 S A L L F F E T S G L F I F F F L Q A A 3 C Y Q L I I S S W L A G F L V I F P P L 4 Y S L I V L I L T S I L T F L A L I F S 5 S S H V I V V S I S Y G S C I F M Y V 6 F P N L M P A V S T N L I A V G K T L 7

GPCRdb(A)
GPCRdb(A)
OR6C76
TM2
2x52 2.52x52 S69
2x56 2.56x56 V73
TM3
3x31 3.31x31 F100
3x33 3.33x33 I102
3x37 3.37x37 S106
TM4
4x56 4.56x56 V152
TM5
5x42 5.42x42 L199
TM6
6x55 6.55x55 Y256