PDB
9LLA
Resolution
3.3 Å
Released
Jan. 14, 2026
Receptor
5-HT2A
Class
A
Species
Homo sapiens
Ligand
Ariadne
Function
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
Ariadne D155 3.32x32 TM3 polar (charge-assisted hydrogen bond)
Ariadne V156 3.33x33 TM3 hydrophobic
Ariadne S159 3.36x36 TM3 polar (hydrogen bond)
Ariadne T160 3.37x37 TM3 Van der Waals
Ariadne F234 5.38x39 TM5 hydrophobic
Ariadne F234 5.38x39 TM5 Van der Waals
Ariadne G238 5.42x43 TM5 Van der Waals
Ariadne S242 5.46x461 TM5 Van der Waals
Ariadne F339 6.51x51 TM6 Van der Waals
Ariadne F339 6.51x51 TM6 hydrophobic
Ariadne F340 6.52x52 TM6 Van der Waals
Ariadne F340 6.52x52 TM6 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 K K L Q ICL1ECL1 Y R W P L ECL1ICL2 P I H H S R F N ICL2ECL2 D S K V F K E G S C L L A ECL2ICL3 G T R A K L A S F S F L P Q S S L S S E K L F Q R S I H R E P G S Y T G R R T ICL3ECL3 K E S C ECL3N-term M D I L C E E N T S L S S T T N S L M Q L N D D T R L Y S N D F N S G E A N T S D A F N W T V D S E N R T N L S C E G C L S P S C L S L N-termC-term Q Y K E N K K P L Q L I L V N T I P A L A Y K S S Q L Q M G Q K K N S K Q D A K T T D N D C S M V A L G K Q H S E E A S K D N S D G V N E K V S C V C-term L H L Q E K N W S A L L T A V V I I L T I A G N I L V I M A V S L E N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q K E A T L C V S D L M Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T F S R Y R S A Y I Q C
Helix box plot — Download: PNG | SVG I N G A I T L I I V V A T L L A S W N K 1 M S L A I A D M L L G L F V M P V S M L T 2 A C L H M I S A T S F L V D L Y I W V A 3 A F L K I I A V W T I S V G I S M P I 4 Y T I V M I T L P I F F S V F S G I L V F 5 G I V F F L F V V M W C P F F I T N I M 6 L P N V A S S L Y G I W V F V N L L A 7

GPCRdb(A)
GPCRdb(A)
5-HT2A receptor
TM3
3x32 3.32x32 D155
3x33 3.33x33 V156
3x36 3.36x36 S159
3x37 3.37x37 T160
TM5
5x39 5.38x39 F234
5x43 5.42x43 G238
5x461 5.46x461 S242
TM6
6x51 6.51x51 F339
6x52 6.52x52 F340