PDB
9LLB
Resolution
3.0 Å
Released
Jan. 14, 2026
Receptor
5-HT2A
Class
A
Species
Homo sapiens
Ligand
Function
DOI-NBOMe
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
DOI-NBOMe L123 2.53x53 TM2 Van der Waals
DOI-NBOMe D155 3.32x32 TM3 polar (charge-charge)
DOI-NBOMe D155 3.32x32 TM3 polar (hydrogen bond)
DOI-NBOMe V156 3.33x33 TM3 hydrophobic
DOI-NBOMe S159 3.36x36 TM3 Van der Waals
DOI-NBOMe T160 3.37x37 TM3 Van der Waals
DOI-NBOMe L229 45.52x52 ECL2 Van der Waals
DOI-NBOMe F234 5.38x39 TM5 Van der Waals
DOI-NBOMe V235 5.39x40 TM5 Van der Waals
DOI-NBOMe G238 5.42x43 TM5 Van der Waals
DOI-NBOMe S239 5.43x44 TM5 Van der Waals
DOI-NBOMe S242 5.46x461 TM5 Van der Waals
DOI-NBOMe W336 6.48x48 TM6 hydrophobic
DOI-NBOMe F339 6.51x51 TM6 hydrophobic
DOI-NBOMe F339 6.51x51 TM6 aromatic (edge-to-face)
DOI-NBOMe F340 6.52x52 TM6 hydrophobic
DOI-NBOMe F340 6.52x52 TM6 aromatic (edge-to-face)
DOI-NBOMe N343 6.55x55 TM6 Van der Waals
DOI-NBOMe G369 7.42x41 TM7 Van der Waals
DOI-NBOMe Y370 7.43x42 TM7 Van der Waals

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ICL1 K K L Q ICL1ECL1 Y R W P L ECL1ICL2 P I H H S R F N ICL2ECL2 D S K V F K E G S C L L A ECL2ICL3 G T R A K L A S F S F L P Q S S L S S E K L F Q R S I H R E P G S Y T G R R T ICL3ECL3 K E S C ECL3N-term M D I L C E E N T S L S S T T N S L M Q L N D D T R L Y S N D F N S G E A N T S D A F N W T V D S E N R T N L S C E G C L S P S C L S L N-termC-term Q Y K E N K K P L Q L I L V N T I P A L A Y K S S Q L Q M G Q K K N S K Q D A K T T D N D C S M V A L G K Q H S E E A S K D N S D G V N E K V S C V C-term L H L Q E K N W S A L L T A V V I I L T I A G N I L V I M A V S L E N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q K E A T L C V S D L M Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T F S R Y R S A Y I Q C
Helix box plot — Download: PNG | SVG I N G A I T L I I V V A T L L A S W N K 1 M S L A I A D M L L G L F V M P V S M L T 2 A C L H M I S A T S F L V D L Y I W V A 3 A F L K I I A V W T I S V G I S M P I 4 Y T I V M I T L P I F F S V F S G I L V F 5 G I V F F L F V V M W C P F F I T N I M 6 L P N V A S S L Y G I W V F V N L L A 7

GPCRdb(A)
GPCRdb(A)
5-HT2A receptor
TM2
2x53 2.53x53 L123
TM3
3x32 3.32x32 D155
3x33 3.33x33 V156
3x36 3.36x36 S159
3x37 3.37x37 T160
ECL2
45x52 45.52x52 L229
TM5
5x39 5.38x39 F234
5x40 5.39x40 V235
5x43 5.42x43 G238
5x44 5.43x44 S239
5x461 5.46x461 S242
TM6
6x48 6.48x48 W336
6x51 6.51x51 F339
6x52 6.52x52 F340
6x55 6.55x55 N343
TM7
7x41 7.42x41 G369
7x42 7.43x42 Y370