PDB
9LQZ
Resolution
2.6 Å
Released
Feb. 4, 2026
Receptor
apelin
Class
A
Species
Homo sapiens
Ligand
azelaprag
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
azelaprag W85 2.60x60 TM2 aromatic (face-to-edge)
azelaprag I109 3.32x32 TM3 hydrophobic
azelaprag F110 3.33x33 TM3 aromatic (face-to-edge)
azelaprag R168 4.64x65 TM4 polar (charge-assisted hydrogen bond)
azelaprag W261 6.48x48 TM6 hydrophobic
azelaprag Y264 6.51x51 TM6 Van der Waals
azelaprag Y264 6.51x51 TM6 polar (hydrogen bond)
azelaprag K268 6.55x55 TM6 polar (charge-assisted hydrogen bond)
azelaprag Y271 6.58x58 TM6 Van der Waals
azelaprag Y271 6.58x58 TM6 aromatic (face-to-face)
azelaprag L287 7.31x30 TM7 hydrophobic
azelaprag L287 7.31x30 TM7 Van der Waals
azelaprag M288 7.32x31 TM7 Van der Waals
azelaprag F291 7.35x34 TM7 aromatic (edge-to-face)
azelaprag F291 7.35x34 TM7 Van der Waals
azelaprag T295 7.39x38 TM7 Van der Waals
azelaprag Y299 7.43x42 TM7 polar (hydrogen bond)
azelaprag Y299 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 S R E K R ICL1ECL1 Y D W P F ECL1ICL2 P V A N A R L R ICL2ECL2 T T G D L E N T T K V Q C Y M D Y S M V A T V S ECL2ICL3 R K E ICL3ECL3 L H W ECL3N-term M E E G G D F D N Y Y G A D N Q S E C E Y T D W K S S G N-termC-term Q S R C A G T S H S S S G E K S A S Y S S G H S Q G P G P N M G K G G E Q M H E K S I P Y S Q E T L V V D C-term A L I P A I Y M L V F L L G T T G N G L V L W T V F R S R S A D I F I A S L A V A D L T F V V T L P L W A T Y T Y R D G T F F C K L S S Y L I F V N M Y A S V F C L T G L S F D R Y L A I V R L R V S G A V A T A V L W V L A A L L A M P V M V L R S E W A W E V G L G V S S T T V G F V V P F T I M L T C Y F F I A Q T I A G H F R I E G L R K R R R L L S I I V V L V V T F A L C W M P Y H L V K T L Y M L G S L P C D F D L F L M N I F P Y C T C I S Y V N S C L N P F L Y A F F D P R C T S G F R Q A M L C C
Helix box plot — Download: PNG | SVG G N G T T G L L F V L M Y I A P I L A 1 A S L A V A D L T F V V T L P L W A T Y 2 G T L C F V S A Y M N V F I L Y S S L K 3 G A V A T A V L W V L A A L L A M P V 4 Y C T L M I T F P V V F G V T T S S V G L 5 V V L V V T F A L C W M P Y H L V K T L 6 F P N L C S N V Y S I C T C Y P F I N 7

GPCRdb(A)
GPCRdb(A)
apelin receptor
TM2
2x60 2.60x60 W85
TM3
3x32 3.32x32 I109
3x33 3.33x33 F110
TM4
4x65 4.64x65 R168
TM6
6x48 6.48x48 W261
6x51 6.51x51 Y264
6x55 6.55x55 K268
6x58 6.58x58 Y271
TM7
7x30 7.31x30 L287
7x31 7.32x31 M288
7x34 7.35x34 F291
7x38 7.39x38 T295
7x42 7.43x42 Y299