PDB
9LY2
Resolution
3.1 Å
Released
March 4, 2026
Receptor
PTH1
Class
B1
Species
Homo sapiens
Ligand
Long-acting parathyroid hormone analog
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
Long-acting parathyroid hormone analog M32 N-term polar (hydrogen bond)
Long-acting parathyroid hormone analog T33 N-term Van der Waals
Long-acting parathyroid hormone analog K34 N-term Van der Waals
Long-acting parathyroid hormone analog Q37 N-term polar (hydrogen bond)
Long-acting parathyroid hormone analog L41 N-term hydrophobic
Long-acting parathyroid hormone analog L41 N-term Van der Waals
Long-acting parathyroid hormone analog I135 N-term hydrophobic
Long-acting parathyroid hormone analog Y136 N-term hydrophobic
Long-acting parathyroid hormone analog Y136 N-term Van der Waals
Long-acting parathyroid hormone analog D137 N-term polar (charge-assisted hydrogen bond)
Long-acting parathyroid hormone analog N161 N-term Van der Waals
Long-acting parathyroid hormone analog N161 N-term polar (hydrogen bond)
Long-acting parathyroid hormone analog R162 N-term Van der Waals
Long-acting parathyroid hormone analog A165 N-term Van der Waals
Long-acting parathyroid hormone analog A165 N-term polar (hydrogen bond with backbone)
Long-acting parathyroid hormone analog N166 N-term Van der Waals
Long-acting parathyroid hormone analog N166 N-term polar (hydrogen bond)
Long-acting parathyroid hormone analog Y167 N-term Van der Waals
Long-acting parathyroid hormone analog Y167 N-term aromatic (face-to-edge)
Long-acting parathyroid hormone analog Y167 N-term polar (hydrogen bond with backbone)
Long-acting parathyroid hormone analog S168 N-term polar (hydrogen bond with backbone)
Long-acting parathyroid hormone analog S168 N-term Van der Waals
Long-acting parathyroid hormone analog C170 N-term Van der Waals
Long-acting parathyroid hormone analog C170 N-term hydrophobic
Long-acting parathyroid hormone analog V171 N-term Van der Waals
Long-acting parathyroid hormone analog L174 1.26x26 TM1 hydrophobic
Long-acting parathyroid hormone analog L174 1.26x26 TM1 Van der Waals
Long-acting parathyroid hormone analog E177 1.29x29 TM1 polar (charge-assisted hydrogen bond)
Long-acting parathyroid hormone analog E177 1.29x29 TM1 polar (hydrogen bond with backbone)
Long-acting parathyroid hormone analog E180 1.32x32 TM1 Van der Waals
Long-acting parathyroid hormone analog R181 1.33x33 TM1 Van der Waals
Long-acting parathyroid hormone analog F184 1.36x36 TM1 Van der Waals
Long-acting parathyroid hormone analog F184 1.36x36 TM1 aromatic (edge-to-face)
Long-acting parathyroid hormone analog L187 1.39x39 TM1 Van der Waals
Long-acting parathyroid hormone analog L187 1.39x39 TM1 hydrophobic
Long-acting parathyroid hormone analog R233 2.60x60 TM2 polar (charge-assisted hydrogen bond)
Long-acting parathyroid hormone analog D241 2.68x68 TM2 polar (charge-assisted hydrogen bond)
Long-acting parathyroid hormone analog Y245 2.72x72 TM2 Van der Waals
Long-acting parathyroid hormone analog Y245 2.72x72 TM2 hydrophobic
Long-acting parathyroid hormone analog F288 3.36x36 TM3 hydrophobic
Long-acting parathyroid hormone analog F288 3.36x36 TM3 Van der Waals
Long-acting parathyroid hormone analog L289 3.37x37 TM3 hydrophobic
Long-acting parathyroid hormone analog L289 3.37x37 TM3 Van der Waals
Long-acting parathyroid hormone analog L292 3.40x40 TM3 hydrophobic
Long-acting parathyroid hormone analog Y296 3.44x44 TM3 Van der Waals
Long-acting parathyroid hormone analog D353 45.52x52 ECL2 polar (hydrogen bond with backbone)
Long-acting parathyroid hormone analog D353 45.52x52 ECL2 Van der Waals
Long-acting parathyroid hormone analog L354 ECL2 Van der Waals
Long-acting parathyroid hormone analog L354 ECL2 hydrophobic
Long-acting parathyroid hormone analog S355 ECL2 Van der Waals
Long-acting parathyroid hormone analog K360 5.36x37 TM5 Van der Waals
Long-acting parathyroid hormone analog Q364 5.40x40 TM5 Van der Waals
Long-acting parathyroid hormone analog I367 5.43x43 TM5 Van der Waals
Long-acting parathyroid hormone analog L368 5.44x44 TM5 Van der Waals
Long-acting parathyroid hormone analog L368 5.44x44 TM5 hydrophobic
Long-acting parathyroid hormone analog T427 6.59x59 TM6 Van der Waals
Long-acting parathyroid hormone analog T427 6.59x59 TM6 polar (hydrogen bond with backbone)
Long-acting parathyroid hormone analog Y429 ECL3 Van der Waals
Long-acting parathyroid hormone analog Y429 ECL3 hydrophobic
Long-acting parathyroid hormone analog T430 ECL3 Van der Waals
Long-acting parathyroid hormone analog T430 ECL3 polar (hydrogen bond with backbone)
Long-acting parathyroid hormone analog V432 ECL3 Van der Waals
Long-acting parathyroid hormone analog W437 7.35x34 TM7 polar (hydrogen bond)
Long-acting parathyroid hormone analog W437 7.35x34 TM7 polar (hydrogen bond)
Long-acting parathyroid hormone analog E444 7.42x41 TM7 Van der Waals
Long-acting parathyroid hormone analog M445 7.43x42 TM7 hydrophobic
Long-acting parathyroid hormone analog M445 7.43x42 TM7 Van der Waals
Long-acting parathyroid hormone analog N448 7.46x45 TM7 polar (hydrogen bond)
Long-acting parathyroid hormone analog N448 7.46x45 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R R L H ICL1ECL1 L D E A E R L T E E E L R A I A Q A P P P P A T A A A ECL1ICL2 A F F ICL2ECL2 N T G C W D L S S ECL2ICL3 R E T N A G R C ICL3ECL3 P Y T E V S ECL3N-term M G T A R I A P G L A L L L C C P V L S S A Y A L V D A D D V M T K E E Q I F L L H R A Q A Q C E K R L K E V L Q R P A S I M E S D K G W T S A S T S G K P R K D K A S G K L Y P E S E E D K E A P T G S R Y R G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K N-termC-term S G S S S Y S Y G P M V S H T S V T N V G P R V G L G L P L S P R L L P T A T T N G H P Q L P G H A K P G T P A L E T L E T T P P A M A A P K D D G F L N G S C S G L D E E A S G P E R P P A L L Q E E W E T V M C-term F L T N E T R E R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S G A T G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L D T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E I K K W T L K R K V Q A E S W S R A L D F A R
Helix box plot — Download: PNG | SVG T L S A L S V S Y G V T Y I M G L R D F 1 M H L F L S F M L R A V S I F V K D A V 2 V L I W Y Y N T A L F Y L F F T V A V R 3 Y L W G F T V G F W G L P A V F V A V W V 4 F L I F N L V I S A L I P V Q I I W K K N 5 L V L M P L F G V H Y I V F M A T 6 I A V F F G Q F S N F L M E Y H M Q V 7

GPCRdb(A)
GPCRdb(B)
PTH1 receptor
TM1
1x22 1.26x26 L174
1x25 1.29x29 E177
1x28 1.32x32 E180
1x29 1.33x33 R181
1x32 1.36x36 F184
1x35 1.39x39 L187
TM2
2x53 2.60x60 R233
2x61 2.68x68 D241
2x65 2.72x72 Y245
TM3
3x32 3.36x36 F288
3x33 3.37x37 L289
3x36 3.40x40 L292
3x40 3.44x44 Y296
ECL2
45x52 45.52x52 D353
TM5
5x41 5.36x37 K360
5x44 5.40x40 Q364
5x47 5.43x43 I367
5x48 5.44x44 L368
TM6
6x54 6.59x59 T427
TM7
7x30 7.35x34 W437
7x37 7.42x41 E444
7x38 7.43x42 M445
7x41 7.46x45 N448