PDB
9M1U
Resolution
2.6 Å
Released
June 17, 2026
Receptor
oxoglutarate
Class
A
Species
Homo sapiens
Ligand
succinic acid
Function
Agonist
Reference
10.1038/S44318-026-00823-Y

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Ligand Amino Acid Generic Number Segment Interaction Type
succinic acid Y40 1.39x39 TM1 polar (hydrogen bond)
succinic acid Y40 1.39x39 TM1 Van der Waals
succinic acid L89 2.60x60 TM2 Van der Waals
succinic acid L89 2.60x60 TM2 hydrophobic
succinic acid Y93 2.64x64 TM2 Van der Waals
succinic acid Y93 2.64x64 TM2 polar (hydrogen bond)
succinic acid R110 3.29x29 TM3 polar (charge-assisted hydrogen bond)
succinic acid F113 3.32x32 TM3 hydrophobic
succinic acid F113 3.32x32 TM3 Van der Waals
succinic acid H114 3.33x33 TM3 polar (hydrogen bond)
succinic acid H114 3.33x33 TM3 Van der Waals
succinic acid D185 45.52x52 ECL2 Van der Waals
succinic acid R288 7.39x38 TM7 polar (charge-assisted hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 M R P W ICL1ECL1 G E N W I F ECL1ICL2 P M S C F S I H ICL2ECL2 T S T N R T N R S A C L D L T S S D E ECL2ICL3 G L Q T ICL3ECL3 R L L S I ECL3N-term M N E P L D Y L A N A S D F P D Y A A A F G N C T D E N I P N-termC-term C K V S G N L E Q A K K I S Y S N N P C-term L K M H Y L P V I Y G I I F L V G F P G N A V V I S T Y I F K K S S T I I M L N L A C T D L L Y L T S L P F L I H Y Y A S G D F M C K F I R F S F H F N L Y S S I L F L T C F S I F R Y C V I I H K T R C A V V A C A V V W I I S L V A V I P M T F L I L N T I K W Y N L I L T A T T F C L P L V I V T L C Y T T I I H T L T H D S C L K Q K A R R L T I L L L L A F Y V C F L P F H I L R V I R I E S S C S I E N Q I H E A Y I V S R P L A A L N T F G N L L L Y V V V S D N V C S F Q Q A T V R
Helix box plot — Download: PNG | SVG A N G P F G V L F I I G Y I V P L Y H M 1 L N L A C T D L L Y L T S L P F L I H Y 2 C T L F L I S S Y L N F H F S F R I F K 3 A V V A C A V V W I I S L V A V I P M 4 Y C L T V I V L P L C F T T A T L I L N Y 5 I L L L L A F Y V C F L P F H I L R V I 6 L L N G F T N L A A L P R S V I Y A E 7

GPCRdb(A)
GPCRdb(A)
oxoglutarate receptor
TM1
1x39 1.39x39 Y40
TM2
2x60 2.60x60 L89
2x64 2.64x64 Y93
TM3
3x29 3.29x29 R110
3x32 3.32x32 F113
3x33 3.33x33 H114
ECL2
45x52 45.52x52 D185
TM7
7x38 7.39x38 R288