PDB
9M42
Resolution
3.2 Å
Released
Jan. 21, 2026
Receptor
GPR139
Class
A
Species
Homo sapiens
Ligand
Function
Compound 1.1(S)
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
Compound 1.1(S) I80 2.57x57 TM2 hydrophobic
Compound 1.1(S) D84 2.61x61 TM2 Van der Waals
Compound 1.1(S) E105 3.29x29 TM3 Van der Waals
Compound 1.1(S) E108 3.32x32 TM3 Van der Waals
Compound 1.1(S) F109 3.33x33 TM3 hydrophobic
Compound 1.1(S) I112 3.36x36 TM3 hydrophobic
Compound 1.1(S) W166 ECL2 polar (hydrogen bond)
Compound 1.1(S) I169 ECL2 Van der Waals
Compound 1.1(S) R244 6.51x51 TM6 hydrophobic
Compound 1.1(S) R244 6.51x51 TM6 aromatic (pi-cation)
Compound 1.1(S) R244 6.51x51 TM6 polar (hydrogen bond)
Compound 1.1(S) M247 6.54x54 TM6 hydrophobic
Compound 1.1(S) I248 6.55x55 TM6 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 Q L V A R R Q ICL1ECL1 N M Q ECL1ICL2 P L K Y H T V S ICL2ECL2 W P N I W T E D Y I S ECL2ICL3 S N F R L R ICL3ECL3 A P I Q ECL3N-term M E H T H A H L A A N S S L S W W S P G S A C G L G N-termC-term K C Q K Q P V Q F Y T N H N F S I T S S P W I S P A N S H C I K M L V Y Q Y D K N G K P I K V S P C-term F V P V V Y Y S L L L C L G L P A N I L T V I I L S K S S Y N Y L L A L A A A D I L V L F F I V F V D F L L E D F I L M P Q V P D K I I E V L E F S S I H T S I W I T V P L T I D R Y I A V C H Y P A R T R K V I V S V Y I T C F L T S I P Y Y W T S V H H V L I W I H C F T V Y L V P C S I F F I L N S I I V Y K L R R K G Y S T G K T T A I L F T I T S I F A T L W A P R I I M I L Y H L Y G N R W L V H I M S D I A N M L A L L N T A I N F F L Y C F I S K R A A A F F F R T M T L K A
Helix box plot — Download: PNG | SVG I N A P L G L C L L L S Y Y V V P V F 1 L A L A A A D I L V L F F I V F V D F L 2 P V T I W I S T H I S S F E L V E I I K 3 T R K V I V S V Y I T C F L T S I P Y 4 N L I F F I S C P V L Y V T F C H I W I L 5 F T I T S I F A T L W A P R I I M I L Y 6 F F N I A T N L L A L M N A I D S M I 7

GPCRdb(A)
GPCRdb(A)
GPR139
TM2
2x57 2.57x57 I80
2x61 2.61x61 D84
TM3
3x29 3.29x29 E105
3x32 3.32x32 E108
3x33 3.33x33 F109
3x36 3.36x36 I112
TM6
6x51 6.51x51 R244
6x54 6.54x54 M247
6x55 6.55x55 I248