PDB
9M8P
Resolution
3.4 Å
Released
Sept. 24, 2025
Receptor
GPR3
Class
A
Species
Homo sapiens
Ligands
Function
N-oleoylethanolamide
Agonist
AF64394 (B:401)
NAM
AF64394 (A:404)
NAM
Reference
—
N-oleoylethanolamide AF64394 (B:401) AF64394 (A:404)

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Ligand Amino Acid Generic Number Segment Interaction Type
N-oleoylethanolamide L47 1.39x39 TM1 Van der Waals
N-oleoylethanolamide L93 2.57x57 TM2 Van der Waals
N-oleoylethanolamide H96 2.60x60 TM2 polar (hydrogen bond)
N-oleoylethanolamide V113 3.29x29 TM3 Van der Waals
N-oleoylethanolamide L116 3.32x32 TM3 Van der Waals
N-oleoylethanolamide A117 3.33x33 TM3 Van der Waals
N-oleoylethanolamide F120 3.36x36 TM3 hydrophobic
N-oleoylethanolamide T121 3.37x37 TM3 hydrophobic
N-oleoylethanolamide I124 3.40x40 TM3 hydrophobic
AF64394 (B:401) L128 3.44x44 TM3 hydrophobic
AF64394 (B:401) V132 3.48x48 TM3 hydrophobic
AF64394 (B:401) Y135 3.51x51 TM3 Van der Waals
AF64394 (B:401) L136 3.52x52 TM3 Van der Waals
AF64394 (B:401) V155 4.44x44 TM4 Van der Waals
AF64394 (B:401) M156 4.45x45 TM4 hydrophobic
AF64394 (B:401) L159 4.48x48 TM4 hydrophobic
N-oleoylethanolamide V187 ECL2 Van der Waals
N-oleoylethanolamide L190 ECL2 hydrophobic
N-oleoylethanolamide L198 5.43x43 TM5 hydrophobic
N-oleoylethanolamide A201 5.46x46 TM5 Van der Waals
N-oleoylethanolamide F202 5.47x47 TM5 hydrophobic
N-oleoylethanolamide V205 5.50x50 TM5 hydrophobic
AF64394 (B:401) I208 5.53x53 TM5 Van der Waals
AF64394 (A:404) Q211 5.56x56 TM5 polar (hydrogen bond)
AF64394 (A:404) A214 5.59x59 TM5 hydrophobic
AF64394 (A:404) Q215 5.60x60 TM5 Van der Waals
AF64394 (A:404) R218 5.63x63 TM5 polar (hydrogen bond)
N-oleoylethanolamide W260 6.48x48 TM6 hydrophobic
N-oleoylethanolamide F263 6.51x51 TM6 hydrophobic
N-oleoylethanolamide T264 6.52x52 TM6 hydrophobic
N-oleoylethanolamide L283 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 P A F R ICL1ECL1 C I G ECL1ICL2 A L T Y Y ICL2ECL2 V L A W N C L D G L T T C G V V Y P L ECL2ICL3 H L ICL3ECL3 D A H S ECL3N-term M M W G A G S P L A W L S A G S G N V N V S S V G P A E G P T G P A A P L P S P N-termC-term C C S S S K I P F R S R S P S D V C-term K A W D V V L C I S G T L V S C E N A L V V A I I V G T A P M F L L V G S L A V A D L L A G L G L V L H F A A V F S A E M S L V L V G V L A M A F T A S I G S L L A I T V D R Y L S L Y N S E T T V T R T Y V M L A L V W G G A L G L G L L P S K N H L V V L A I A F F M V F G I M L Q L Y A Q I C R I V C R H A Q Q I A L Q R L P A S H Y V A T R K G I A T L A V V L G A F A A C W L P F T V Y C L L G P P L Y T Y L T L L P A T Y N S M I N P I I Y A F R N Q D L W A V Q K V V C C
Helix box plot — Download: PNG | SVG A N E C S V L T G S I C L V V D W A K 1 G S L A V A D L L A G L G L V L H F A A 2 A L L S G I S A T F A M A L V G V L V L 3 T Y V M L A L V W G G A L G L G L L P 4 Y L Q L M I G F V M F F A I A L V V L H 5 A V V L G A F A A C W L P F T V Y C L L 6 I P N I M S N Y T A P L L T L Y T Y L 7

GPCRdb(A)
GPCRdb(A)
GPR3
TM1
1x39 1.39x39 L47
TM2
2x57 2.57x57 L93
2x60 2.60x60 H96
TM3
3x29 3.29x29 V113
3x32 3.32x32 L116
3x33 3.33x33 A117
3x36 3.36x36 F120
3x37 3.37x37 T121
3x40 3.40x40 I124
3x44 3.44x44 L128
3x48 3.48x48 V132
3x51 3.51x51 Y135
3x52 3.52x52 L136
TM4
4x44 4.44x44 V155
4x45 4.45x45 M156
4x48 4.48x48 L159
TM5
5x43 5.43x43 L198
5x46 5.46x46 A201
5x47 5.47x47 F202
5x50 5.50x50 V205
5x53 5.53x53 I208
5x56 5.56x56 Q211
5x59 5.59x59 A214
5x60 5.60x60 Q215
5x63 5.63x63 R218
TM6
6x48 6.48x48 W260
6x51 6.51x51 F263
6x52 6.52x52 T264
TM7
7x38 7.39x38 L283