PDB
9MQI
Resolution
3.3 Å
Released
Feb. 12, 2025
Receptor
μ
Class
A
Species
Homo sapiens
Ligand
Function
#020_E1
Antagonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
#020_E1 Q126 2.60x60 TM2 Van der Waals
#020_E1 Y130 2.64x64 TM2 hydrophobic
#020_E1 D149 3.32x32 TM3 hydrophobic
#020_E1 Y150 3.33x33 TM3 aromatic (edge-to-face)
#020_E1 Y150 3.33x33 TM3 hydrophobic
#020_E1 M153 3.36x36 TM3 hydrophobic
#020_E1 K235 5.39x40 TM5 Van der Waals
#020_E1 W295 6.48x48 TM6 Van der Waals
#020_E1 I298 6.51x51 TM6 hydrophobic
#020_E1 H299 6.52x52 TM6 aromatic (edge-to-face)
#020_E1 V302 6.55x55 TM6 hydrophobic
#020_E1 W320 7.35x34 TM7 Van der Waals
#020_E1 I324 7.39x38 TM7 hydrophobic
#020_E1 Y328 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A A P T N A S N C T D A L A Y S S C S P A P S P G S W V N L S H L D G N L S D P C G P N R T D L G G R D S L C P P T G S P S N-termC-term P T S S N I E Q Q N S T R I R Q N T R D H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I I N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I I N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM2
2x60 2.60x60 Q126
2x64 2.64x64 Y130
TM3
3x32 3.32x32 D149
3x33 3.33x33 Y150
3x36 3.36x36 M153
TM5
5x40 5.39x40 K235
TM6
6x48 6.48x48 W295
6x51 6.51x51 I298
6x52 6.52x52 H299
6x55 6.55x55 V302
TM7
7x34 7.35x34 W320
7x38 7.39x38 I324
7x42 7.43x42 Y328