PDB
9MXU
Resolution
2.5 Å
Released
April 22, 2026
Receptor
GLP-1
Class
B1
Species
Homo sapiens
Ligand
Glucagon
Function
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
Glucagon S31 N-term polar (hydrogen bond)
Glucagon L32 N-term polar (hydrogen bond with backbone)
Glucagon L32 N-term polar (hydrogen bond)
Glucagon T35 N-term Van der Waals
Glucagon V36 N-term Van der Waals
Glucagon E68 N-term polar (hydrogen bond with backbone)
Glucagon E68 N-term Van der Waals
Glucagon Y69 N-term polar (hydrogen bond with backbone)
Glucagon Y69 N-term Van der Waals
Glucagon P86 N-term Van der Waals
Glucagon L89 N-term Van der Waals
Glucagon P90 N-term Van der Waals
Glucagon P137 N-term hydrophobic
Glucagon P137 N-term Van der Waals
Glucagon E138 1.33x33 TM1 polar (charge-assisted hydrogen bond)
Glucagon L141 1.36x36 TM1 polar (hydrogen bond with backbone)
Glucagon L141 1.36x36 TM1 Van der Waals
Glucagon L144 1.39x39 TM1 Van der Waals
Glucagon L144 1.39x39 TM1 hydrophobic
Glucagon Y145 1.40x40 TM1 Van der Waals
Glucagon Y148 1.43x43 TM1 aromatic (edge-to-face)
Glucagon Y148 1.43x43 TM1 polar (hydrogen bond)
Glucagon Y152 1.47x47 TM1 polar (hydrogen bond)
Glucagon Y152 1.47x47 TM1 polar (hydrogen bond)
Glucagon R190 2.60x60 TM2 Van der Waals
Glucagon V194 2.64x64 TM2 polar (hydrogen bond)
Glucagon K197 2.67x67 TM2 polar (charge-assisted hydrogen bond)
Glucagon L201 2.71x71 TM2 hydrophobic
Glucagon L201 2.71x71 TM2 Van der Waals
Glucagon Y205 2.75x75 TM2 polar (hydrogen bond)
Glucagon Y205 2.75x75 TM2 polar (hydrogen bond with backbone)
Glucagon S206 ECL1 Van der Waals
Glucagon T207 ECL1 polar (hydrogen bond)
Glucagon T207 ECL1 polar (charge-assisted hydrogen bond)
Glucagon A209 ECL1 polar (hydrogen bond with backbone)
Glucagon A209 ECL1 Van der Waals
Glucagon W214 ECL1 polar (hydrogen bond)
Glucagon F230 3.33x33 TM3 Van der Waals
Glucagon M233 3.36x36 TM3 Van der Waals
Glucagon Q234 3.37x37 TM3 polar (hydrogen bond)
Glucagon V237 3.40x40 TM3 polar (hydrogen bond)
Glucagon Y241 3.44x44 TM3 polar (charge-assisted hydrogen bond)
Glucagon Y241 3.44x44 TM3 polar (hydrogen bond)
Glucagon T298 45.52x52 ECL2 polar (hydrogen bond with backbone)
Glucagon T298 45.52x52 ECL2 polar (hydrogen bond)
Glucagon R299 ECL2 polar (charge-assisted hydrogen bond)
Glucagon N300 ECL2 polar (hydrogen bond)
Glucagon W306 5.36x37 TM5 polar (hydrogen bond)
Glucagon W306 5.36x37 TM5 polar (charge-assisted hydrogen bond)
Glucagon I309 5.39x39 TM5 Van der Waals
Glucagon R310 5.40x40 TM5 polar (charge-charge)
Glucagon R310 5.40x40 TM5 polar (charge-assisted hydrogen bond)
Glucagon I313 5.43x43 TM5 polar (charge-assisted hydrogen bond)
Glucagon E364 6.53x53 TM6 polar (charge-assisted hydrogen bond)
Glucagon D372 ECL3 polar (charge-assisted hydrogen bond)
Glucagon R380 7.35x34 TM7 polar (charge-assisted hydrogen bond)
Glucagon L384 7.39x38 TM7 polar (hydrogen bond)
Glucagon E387 7.42x41 TM7 polar (charge-assisted hydrogen bond)
Glucagon L388 7.43x42 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
Helix box plot — Download: PNG | SVG V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7

GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x29 1.33x33 E138
1x32 1.36x36 L141
1x35 1.39x39 L144
1x36 1.40x40 Y145
1x39 1.43x43 Y148
1x43 1.47x47 Y152
TM2
2x53 2.60x60 R190
2x57 2.64x64 V194
2x60 2.67x67 K197
2x64 2.71x71 L201
2x68 2.75x75 Y205
TM3
3x29 3.33x33 F230
3x32 3.36x36 M233
3x33 3.37x37 Q234
3x36 3.40x40 V237
3x40 3.44x44 Y241
ECL2
45x52 45.52x52 T298
TM5
5x41 5.36x37 W306
5x43 5.39x39 I309
5x44 5.40x40 R310
5x47 5.43x43 I313
TM6
6x48 6.53x53 E364
TM7
7x30 7.35x34 R380
7x34 7.39x38 L384
7x37 7.42x41 E387
7x38 7.43x42 L388