PDB
9MZF
Resolution
2.5 Å
Released
April 22, 2026
Receptor
GLP-1
Class
B1
Species
Homo sapiens
Ligand
Peptide 15
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
Peptide 15 V30 N-term polar (hydrogen bond with backbone)
Peptide 15 V30 N-term Van der Waals
Peptide 15 S31 N-term Van der Waals
Peptide 15 L32 N-term Van der Waals
Peptide 15 L32 N-term polar (hydrogen bond with backbone)
Peptide 15 T35 N-term Van der Waals
Peptide 15 V36 N-term Van der Waals
Peptide 15 V36 N-term hydrophobic
Peptide 15 W39 N-term aromatic (face-to-edge)
Peptide 15 W39 N-term Van der Waals
Peptide 15 D67 N-term polar (charge-assisted hydrogen bond)
Peptide 15 E68 N-term polar (charge-assisted hydrogen bond)
Peptide 15 Y69 N-term hydrophobic
Peptide 15 Y69 N-term Van der Waals
Peptide 15 Y88 N-term hydrophobic
Peptide 15 Y88 N-term Van der Waals
Peptide 15 P90 N-term Van der Waals
Peptide 15 W91 N-term Van der Waals
Peptide 15 W91 N-term hydrophobic
Peptide 15 R121 N-term polar (charge-assisted hydrogen bond)
Peptide 15 L123 N-term hydrophobic
Peptide 15 L123 N-term Van der Waals
Peptide 15 P137 N-term hydrophobic
Peptide 15 P137 N-term Van der Waals
Peptide 15 E138 1.33x33 TM1 polar (charge-assisted hydrogen bond)
Peptide 15 L141 1.36x36 TM1 hydrophobic
Peptide 15 L141 1.36x36 TM1 Van der Waals
Peptide 15 L144 1.39x39 TM1 Van der Waals
Peptide 15 L144 1.39x39 TM1 hydrophobic
Peptide 15 Y145 1.40x40 TM1 Van der Waals
Peptide 15 Y148 1.43x43 TM1 aromatic (edge-to-face)
Peptide 15 Y148 1.43x43 TM1 Van der Waals
Peptide 15 Y152 1.47x47 TM1 Van der Waals
Peptide 15 K197 2.67x67 TM2 polar (charge-assisted hydrogen bond)
Peptide 15 L201 2.71x71 TM2 Van der Waals
Peptide 15 L201 2.71x71 TM2 hydrophobic
Peptide 15 Y205 2.75x75 TM2 polar (hydrogen bond)
Peptide 15 Y205 2.75x75 TM2 polar (hydrogen bond)
Peptide 15 W214 ECL1 Van der Waals
Peptide 15 W214 ECL1 hydrophobic
Peptide 15 M233 3.36x36 TM3 Van der Waals
Peptide 15 Q234 3.37x37 TM3 polar (hydrogen bond)
Peptide 15 Q234 3.37x37 TM3 Van der Waals
Peptide 15 V237 3.40x40 TM3 hydrophobic
Peptide 15 V237 3.40x40 TM3 Van der Waals
Peptide 15 T298 45.52x52 ECL2 polar (hydrogen bond)
Peptide 15 R299 ECL2 polar (charge-assisted hydrogen bond)
Peptide 15 N300 ECL2 polar (hydrogen bond with backbone)
Peptide 15 N300 ECL2 Van der Waals
Peptide 15 W306 5.36x37 TM5 hydrophobic
Peptide 15 W306 5.36x37 TM5 Van der Waals
Peptide 15 R310 5.40x40 TM5 Van der Waals
Peptide 15 I313 5.43x43 TM5 Van der Waals
Peptide 15 I313 5.43x43 TM5 hydrophobic
Peptide 15 D372 ECL3 polar (charge-assisted hydrogen bond)
Peptide 15 R380 7.35x34 TM7 polar (charge-assisted hydrogen bond)
Peptide 15 L384 7.39x38 TM7 hydrophobic
Peptide 15 L384 7.39x38 TM7 Van der Waals
Peptide 15 E387 7.42x41 TM7 Van der Waals
Peptide 15 L388 7.43x42 TM7 hydrophobic
Peptide 15 L388 7.43x42 TM7 Van der Waals

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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
Helix box plot — Download: PNG | SVG V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7

GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x29 1.33x33 E138
1x32 1.36x36 L141
1x35 1.39x39 L144
1x36 1.40x40 Y145
1x39 1.43x43 Y148
1x43 1.47x47 Y152
TM2
2x60 2.67x67 K197
2x64 2.71x71 L201
2x68 2.75x75 Y205
TM3
3x32 3.36x36 M233
3x33 3.37x37 Q234
3x36 3.40x40 V237
ECL2
45x52 45.52x52 T298
TM5
5x41 5.36x37 W306
5x44 5.40x40 R310
5x47 5.43x43 I313
TM7
7x30 7.35x34 R380
7x34 7.39x38 L384
7x37 7.42x41 E387
7x38 7.43x42 L388