PDB
9N05
Resolution
2.2 Å
Released
April 22, 2026
Receptor
GLP-1
Class
B1
Species
Homo sapiens
Ligand
SRB103Q
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
SRB103Q L32 N-term polar (hydrogen bond with backbone)
SRB103Q L32 N-term Van der Waals
SRB103Q V36 N-term hydrophobic
SRB103Q V36 N-term Van der Waals
SRB103Q W39 N-term aromatic (face-to-edge)
SRB103Q W39 N-term Van der Waals
SRB103Q D67 N-term Van der Waals
SRB103Q E68 N-term Van der Waals
SRB103Q Y69 N-term hydrophobic
SRB103Q Y69 N-term Van der Waals
SRB103Q Y88 N-term Van der Waals
SRB103Q L89 N-term hydrophobic
SRB103Q L89 N-term Van der Waals
SRB103Q W91 N-term hydrophobic
SRB103Q W91 N-term Van der Waals
SRB103Q R121 N-term polar (charge-assisted hydrogen bond)
SRB103Q E138 1.33x33 TM1 polar (hydrogen bond with backbone)
SRB103Q E138 1.33x33 TM1 Van der Waals
SRB103Q L141 1.36x36 TM1 hydrophobic
SRB103Q L141 1.36x36 TM1 Van der Waals
SRB103Q L144 1.39x39 TM1 hydrophobic
SRB103Q L144 1.39x39 TM1 Van der Waals
SRB103Q Y145 1.40x40 TM1 hydrophobic
SRB103Q Y145 1.40x40 TM1 Van der Waals
SRB103Q Y148 1.43x43 TM1 Van der Waals
SRB103Q Y148 1.43x43 TM1 aromatic (edge-to-face)
SRB103Q Y152 1.47x47 TM1 Van der Waals
SRB103Q V194 2.64x64 TM2 Van der Waals
SRB103Q K197 2.67x67 TM2 polar (charge-assisted hydrogen bond)
SRB103Q L201 2.71x71 TM2 hydrophobic
SRB103Q L201 2.71x71 TM2 Van der Waals
SRB103Q Y205 2.75x75 TM2 Van der Waals
SRB103Q Y205 2.75x75 TM2 polar (hydrogen bond)
SRB103Q W214 ECL1 aromatic (edge-to-face)
SRB103Q W214 ECL1 Van der Waals
SRB103Q F230 3.33x33 TM3 Van der Waals
SRB103Q M233 3.36x36 TM3 Van der Waals
SRB103Q Q234 3.37x37 TM3 polar (hydrogen bond)
SRB103Q V237 3.40x40 TM3 Van der Waals
SRB103Q V237 3.40x40 TM3 hydrophobic
SRB103Q T298 45.52x52 ECL2 Van der Waals
SRB103Q T298 45.52x52 ECL2 polar (hydrogen bond)
SRB103Q R299 ECL2 polar (charge-assisted hydrogen bond)
SRB103Q N300 ECL2 Van der Waals
SRB103Q N300 ECL2 polar (hydrogen bond with backbone)
SRB103Q W306 5.36x37 TM5 hydrophobic
SRB103Q W306 5.36x37 TM5 Van der Waals
SRB103Q R310 5.40x40 TM5 Van der Waals
SRB103Q L314 5.44x44 TM5 Van der Waals
SRB103Q D372 ECL3 polar (charge-assisted hydrogen bond)
SRB103Q R380 7.35x34 TM7 polar (charge-assisted hydrogen bond)
SRB103Q L384 7.39x38 TM7 hydrophobic
SRB103Q L384 7.39x38 TM7 Van der Waals
SRB103Q E387 7.42x41 TM7 Van der Waals
SRB103Q L388 7.43x42 TM7 hydrophobic
SRB103Q L388 7.43x42 TM7 Van der Waals

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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
Helix box plot — Download: PNG | SVG V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7

GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x29 1.33x33 E138
1x32 1.36x36 L141
1x35 1.39x39 L144
1x36 1.40x40 Y145
1x39 1.43x43 Y148
1x43 1.47x47 Y152
TM2
2x57 2.64x64 V194
2x60 2.67x67 K197
2x64 2.71x71 L201
2x68 2.75x75 Y205
TM3
3x29 3.33x33 F230
3x32 3.36x36 M233
3x33 3.37x37 Q234
3x36 3.40x40 V237
ECL2
45x52 45.52x52 T298
TM5
5x41 5.36x37 W306
5x44 5.40x40 R310
5x48 5.44x44 L314
TM7
7x30 7.35x34 R380
7x34 7.39x38 L384
7x37 7.42x41 E387
7x38 7.43x42 L388