PDB
9N09
Resolution
2.6 Å
Released
Jan. 28, 2026
Receptor
M4
Class
A
Species
Homo sapiens
Ligand
CHEMBL6164470
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL6164470 L88 2.60x59 TM2 hydrophobic
CHEMBL6164470 Y89 2.61x60 TM2 hydrophobic
CHEMBL6164470 Y92 2.64x63 TM2 hydrophobic
CHEMBL6164470 W98 23.50x50 ECL1 hydrophobic
CHEMBL6164470 W108 3.28x28 TM3 aromatic (edge-to-face)
CHEMBL6164470 L109 3.29x29 TM3 hydrophobic
CHEMBL6164470 D112 3.32x32 TM3 polar (charge-assisted hydrogen bond)
CHEMBL6164470 Y113 3.33x33 TM3 hydrophobic
CHEMBL6164470 Y113 3.33x33 TM3 Van der Waals
CHEMBL6164470 S116 3.36x36 TM3 Van der Waals
CHEMBL6164470 W164 4.57x57 TM4 Van der Waals
CHEMBL6164470 C185 45.50x50 ECL2 Van der Waals
CHEMBL6164470 C185 45.50x50 ECL2 hydrophobic
CHEMBL6164470 W413 6.48x48 TM6 hydrophobic
CHEMBL6164470 W413 6.48x48 TM6 Van der Waals
CHEMBL6164470 Y416 6.51x51 TM6 Van der Waals
CHEMBL6164470 Y416 6.51x51 TM6 hydrophobic
CHEMBL6164470 Y439 7.39x38 TM7 hydrophobic
CHEMBL6164470 Y439 7.39x38 TM7 Van der Waals
CHEMBL6164470 Y443 7.43x42 TM7 Van der Waals
CHEMBL6164470 Y443 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 R Q L Q ICL1ECL1 Y W P L ECL1ICL2 P L T Y P A R R ICL2ECL2 K R T V P D N Q C F I Q F L S ECL2ICL3 G P K E K K A K T L A F L K S P L M K Q S V K K P P P G E A A R E E L R N G K L E E A P P P A L P P P P R P V A D K D T S N E S S S G S A T Q N T K E R P A T E L S T T E A T T P A M P A P P L Q P R A L N P A S R W S K I Q I V T K Q T G N E C V T A I E I V P A T P A G M R P A A N V A R K F A S I A R N Q V R K K ICL3ECL3 Q S C I ECL3N-term M A N F T P V N G S S G N Q S V R L V T S S S H N N-termC-term Y R N I G T A R C-term R Y E T V E M V F I A T V T G S L S L V T V V G N I L V M L S I K V N T V N N Y F L F S L A C A D L I I G A F S M N L Y T V Y I I K G G A V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K T T K M A G L M I A A A W V L S F V L W A P A I L F W Q F V V G N P A V T F G T A I A A F Y L P V V I M T V L Y I H I S L A S R S R V H K H R P E R Q M A A R E R K V T R T I F A I L L A F I L T W T P Y N V M V L V N T F C P D T V W S I G Y W L C Y V N S T I N P A C Y A L C N A T F R H Q F K K T L L L C
Helix box plot — Download: PNG | SVG I N G V V T V L S L S G T V T A I F V M 1 F S L A C A D L I I G F A S M N L Y T V Y 2 I L L N M V S A N S V V Y D L A L W L D 3 A G L M I A A A W V L S F V L W A P A I 4 Y L V T M I V V P L Y F A A I A T G F T V 5 F A I L L A F I L T W T P Y N V M V L V 6 A P N I T S N V Y C L W Y G I S W V T 7

GPCRdb(A)
GPCRdb(A)
M4 receptor
TM2
2x59 2.60x59 L88
2x60 2.61x60 Y89
2x63 2.64x63 Y92
ECL1
23x50 23.50x50 W98
TM3
3x28 3.28x28 W108
3x29 3.29x29 L109
3x32 3.32x32 D112
3x33 3.33x33 Y113
3x36 3.36x36 S116
TM4
4x57 4.57x57 W164
ECL2
45x50 45.50x50 C185
TM6
6x48 6.48x48 W413
6x51 6.51x51 Y416
TM7
7x38 7.39x38 Y439
7x42 7.43x42 Y443