PDB
9N1P
Resolution
2.9 Å
Released
April 22, 2026
Receptor
GLP-1
Class
B1
Species
Homo sapiens
Ligand
SRB103H
Function
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
SRB103H S31 N-term polar (hydrogen bond)
SRB103H S31 N-term Van der Waals
SRB103H L32 N-term polar (hydrogen bond with backbone)
SRB103H L32 N-term Van der Waals
SRB103H T35 N-term Van der Waals
SRB103H E68 N-term Van der Waals
SRB103H Y69 N-term hydrophobic
SRB103H Y69 N-term Van der Waals
SRB103H Y88 N-term Van der Waals
SRB103H Y88 N-term hydrophobic
SRB103H L89 N-term Van der Waals
SRB103H L89 N-term hydrophobic
SRB103H P90 N-term hydrophobic
SRB103H W91 N-term Van der Waals
SRB103H W91 N-term hydrophobic
SRB103H L123 N-term hydrophobic
SRB103H L141 1.36x36 TM1 Van der Waals
SRB103H L141 1.36x36 TM1 hydrophobic
SRB103H Y148 1.43x43 TM1 aromatic (face-to-edge)
SRB103H Y148 1.43x43 TM1 Van der Waals
SRB103H Y152 1.47x47 TM1 polar (hydrogen bond)
SRB103H R190 2.60x60 TM2 Van der Waals
SRB103H K197 2.67x67 TM2 polar (charge-assisted hydrogen bond)
SRB103H L201 2.71x71 TM2 hydrophobic
SRB103H L201 2.71x71 TM2 Van der Waals
SRB103H Y205 2.75x75 TM2 Van der Waals
SRB103H Y205 2.75x75 TM2 polar (hydrogen bond)
SRB103H W214 ECL1 Van der Waals
SRB103H W214 ECL1 aromatic (face-to-edge)
SRB103H Q234 3.37x37 TM3 polar (hydrogen bond)
SRB103H V237 3.40x40 TM3 hydrophobic
SRB103H V237 3.40x40 TM3 Van der Waals
SRB103H T298 45.52x52 ECL2 Van der Waals
SRB103H T298 45.52x52 ECL2 polar (hydrogen bond)
SRB103H R299 ECL2 polar (charge-assisted hydrogen bond)
SRB103H N300 ECL2 Van der Waals
SRB103H W306 5.36x37 TM5 Van der Waals
SRB103H W306 5.36x37 TM5 aromatic (edge-to-face)
SRB103H I309 5.39x39 TM5 Van der Waals
SRB103H R310 5.40x40 TM5 Van der Waals
SRB103H D372 ECL3 polar (charge-assisted hydrogen bond)
SRB103H R380 7.35x34 TM7 polar (charge-assisted hydrogen bond)
SRB103H E387 7.42x41 TM7 Van der Waals
SRB103H L388 7.43x42 TM7 Van der Waals
SRB103H L388 7.43x42 TM7 hydrophobic

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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
Helix box plot — Download: PNG | SVG V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7

GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x32 1.36x36 L141
1x39 1.43x43 Y148
1x43 1.47x47 Y152
TM2
2x53 2.60x60 R190
2x60 2.67x67 K197
2x64 2.71x71 L201
2x68 2.75x75 Y205
TM3
3x33 3.37x37 Q234
3x36 3.40x40 V237
ECL2
45x52 45.52x52 T298
TM5
5x41 5.36x37 W306
5x43 5.39x39 I309
5x44 5.40x40 R310
TM7
7x30 7.35x34 R380
7x37 7.42x41 E387
7x38 7.43x42 L388