PDB
9N1Q
Resolution
3.0 Å
Released
April 22, 2026
Receptor
glucagon
Class
B1
Species
Homo sapiens
Ligand
SRB103H
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
SRB103H A26 N-term polar (hydrogen bond with backbone)
SRB103H A26 N-term Van der Waals
SRB103H Q27 N-term Van der Waals
SRB103H Q27 N-term polar (hydrogen bond with backbone)
SRB103H V28 N-term Van der Waals
SRB103H V28 N-term polar (hydrogen bond with backbone)
SRB103H M29 N-term Van der Waals
SRB103H M29 N-term hydrophobic
SRB103H L32 N-term Van der Waals
SRB103H L32 N-term hydrophobic
SRB103H W36 N-term aromatic (face-to-edge)
SRB103H W36 N-term Van der Waals
SRB103H K64 N-term Van der Waals
SRB103H Y65 N-term hydrophobic
SRB103H Y65 N-term Van der Waals
SRB103H Y84 N-term Van der Waals
SRB103H Y84 N-term hydrophobic
SRB103H L85 N-term hydrophobic
SRB103H L85 N-term Van der Waals
SRB103H P114 N-term Van der Waals
SRB103H P114 N-term hydrophobic
SRB103H R116 N-term polar (charge-assisted hydrogen bond)
SRB103H A118 N-term hydrophobic
SRB103H A118 N-term Van der Waals
SRB103H Q131 1.29x29 TM1 polar (hydrogen bond)
SRB103H Q131 1.29x29 TM1 polar (hydrogen bond)
SRB103H A135 1.33x33 TM1 hydrophobic
SRB103H A135 1.33x33 TM1 Van der Waals
SRB103H Y138 1.36x36 TM1 hydrophobic
SRB103H Y138 1.36x36 TM1 Van der Waals
SRB103H F141 1.39x39 TM1 Van der Waals
SRB103H F141 1.39x39 TM1 hydrophobic
SRB103H Q142 1.40x40 TM1 Van der Waals
SRB103H Y145 1.43x43 TM1 aromatic (face-to-edge)
SRB103H Y145 1.43x43 TM1 Van der Waals
SRB103H Y149 1.47x47 TM1 polar (hydrogen bond)
SRB103H V191 2.64x64 TM2 Van der Waals
SRB103H Y202 2.75x75 TM2 hydrophobic
SRB103H Y202 2.75x75 TM2 Van der Waals
SRB103H Q204 ECL1 polar (hydrogen bond with backbone)
SRB103H Q204 ECL1 Van der Waals
SRB103H G207 ECL1 Van der Waals
SRB103H D208 ECL1 Van der Waals
SRB103H W215 ECL1 Van der Waals
SRB103H Q232 3.37x37 TM3 Van der Waals
SRB103H I235 3.40x40 TM3 hydrophobic
SRB103H I235 3.40x40 TM3 Van der Waals
SRB103H T296 45.52x52 ECL2 Van der Waals
SRB103H T296 45.52x52 ECL2 polar (hydrogen bond)
SRB103H S297 ECL2 Van der Waals
SRB103H N298 ECL2 polar (hydrogen bond)
SRB103H N298 ECL2 Van der Waals
SRB103H W304 ECL2 Van der Waals
SRB103H W304 ECL2 hydrophobic
SRB103H D370 ECL3 polar (charge-assisted hydrogen bond)
SRB103H R378 7.35x34 TM7 polar (charge-assisted hydrogen bond)
SRB103H L382 7.39x38 TM7 hydrophobic
SRB103H L382 7.39x38 TM7 Van der Waals
SRB103H D385 7.42x41 TM7 Van der Waals
SRB103H L386 7.43x42 TM7 hydrophobic
SRB103H L386 7.43x42 TM7 Van der Waals

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ICL1 S K L H ICL1ECL1 Q K I G D D L S V S T W L S D G ECL1ICL2 A T L P E R ICL2ECL2 N V Q C W T S N D N M G F ECL2ICL3 R Q M H H T ICL3ECL3 E H A Q ECL3N-term M P P C Q P Q R P L L L L L L L L A C Q P Q V P S A Q V M D F L F E K W K L Y G D Q C H H N L S L L P P P T E L V C N R T F D K Y S C W P D T P A N T T A N I S C P W Y L P W H H K V Q H R F V F K R C G P D G Q W V R G P R G Q P W R D A S Q C Q M D G E E I E V N-termC-term T S N H R A S S S P G H G P P S K E L Q F G R G G G S Q D S S A E T P L A G G L P R L A E S P F C-term Q K E V A K M Y S S F Q V M Y T V G Y S L S L G A L L L A L A I L G G L C T R N A I H A N L F A S F V L K A S S V L V I D G L L R T R Y S A V A G C R V A A V F M Q Y G I V A N Y C W L L V E G L Y L H N L L G L S F F S L Y L G I G W G A P M L F V V P W A V V K C L F E W W I L R F P V F L A I L I N F F I F V R I V Q L L V A K L R A D Y K F R L A K S T L T L I P L L G V H E V V F A F V T D G T L R S A K L F F D L F L S S F Q G L L V A V L Y C F L N K E L R R W R L W E E V Q S E R W H R G K V L R N
Helix box plot — Download: PNG | SVG L L A G L S L S Y G V T Y M V Q F S S Y 1 A N L F A S F V L K A S S V L V I D G L 2 V L L W C Y N A V I G Y Q M F V A A V R 3 F F S L Y L G G I W G A P M L F V V P W A 4 F I F F N I L I A L F V P F R L I W W 5 L T L I P L L G V H E V V F A F V T D 6 V A V L L G Q F S S L F L D F F L K A 7

GPCRdb(A)
GPCRdb(B)
glucagon receptor
TM1
1x25 1.29x29 Q131
1x29 1.33x33 A135
1x32 1.36x36 Y138
1x35 1.39x39 F141
1x36 1.40x40 Q142
1x39 1.43x43 Y145
1x43 1.47x47 Y149
TM2
2x57 2.64x64 V191
2x68 2.75x75 Y202
TM3
3x33 3.37x37 Q232
3x36 3.40x40 I235
ECL2
45x52 45.52x52 T296
TM7
7x30 7.35x34 R378
7x34 7.39x38 L382
7x37 7.42x41 D385
7x38 7.43x42 L386