PDB
9P0K
Resolution
3.5 Å
Released
April 29, 2026
Receptor
CXCR3
Class
A
Species
Homo sapiens
Ligand
CXCL9
Function
Agonist (partial)
Reference
10.1126/SCIADV.ADZ3767

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Ligand Amino Acid Generic Number Segment Interaction Type
CXCL9 T39 N-term Van der Waals
CXCL9 T39 N-term polar (hydrogen bond with backbone)
CXCL9 S40 N-term polar (hydrogen bond)
CXCL9 S40 N-term polar (hydrogen bond with backbone)
CXCL9 S40 N-term polar (hydrogen bond)
CXCL9 S40 N-term polar (hydrogen bond)
CXCL9 P41 N-term polar (hydrogen bond)
CXCL9 P42 N-term polar (hydrogen bond)
CXCL9 Q45 1.24x24 TM1 polar (hydrogen bond)
CXCL9 D52 1.31x31 TM1 polar (charge-assisted hydrogen bond)
CXCL9 W109 2.60x60 TM2 polar (hydrogen bond)
CXCL9 F131 3.32x32 TM3 Van der Waals
CXCL9 F131 3.32x32 TM3 hydrophobic
CXCL9 N132 3.33x33 TM3 polar (hydrogen bond)
CXCL9 L190 ECL2 Van der Waals
CXCL9 H193 ECL2 polar (hydrogen bond)
CXCL9 D195 ECL2 Van der Waals
CXCL9 E196 ECL2 polar (hydrogen bond with backbone)
CXCL9 E196 ECL2 Van der Waals
CXCL9 R197 ECL2 polar (charge-assisted hydrogen bond)
CXCL9 R197 ECL2 polar (hydrogen bond with backbone)
CXCL9 L198 ECL2 Van der Waals
CXCL9 H202 ECL2 polar (hydrogen bond)
CXCL9 C203 45.50x50 ECL2 polar (hydrogen bond with backbone)
CXCL9 C203 45.50x50 ECL2 Van der Waals
CXCL9 Q204 45.51x51 ECL2 polar (hydrogen bond)
CXCL9 Y205 45.52x52 ECL2 polar (hydrogen bond with backbone)
CXCL9 Y205 45.52x52 ECL2 Van der Waals
CXCL9 P208 5.31x32 TM5 Van der Waals
CXCL9 Q209 5.32x33 TM5 polar (hydrogen bond)
CXCL9 Q209 5.32x33 TM5 polar (hydrogen bond)
CXCL9 R212 5.35x36 TM5 polar (charge-assisted hydrogen bond)
CXCL9 T213 5.36x37 TM5 Van der Waals
CXCL9 R216 5.39x40 TM5 polar (charge-charge)
CXCL9 R216 5.39x40 TM5 polar (charge-assisted hydrogen bond)
CXCL9 Q219 5.42x43 TM5 polar (hydrogen bond)
CXCL9 Y271 6.51x51 TM6 polar (hydrogen bond)
CXCL9 D278 6.58x58 TM6 polar (charge-assisted hydrogen bond)
CXCL9 D278 6.58x58 TM6 polar (charge-charge)
CXCL9 D282 6.62x62 TM6 polar (charge-charge)
CXCL9 D282 6.62x62 TM6 polar (charge-assisted hydrogen bond)
CXCL9 R288 ECL3 Van der Waals
CXCL9 N289 7.24x23 TM7 Van der Waals
CXCL9 C290 7.25x24 TM7 Van der Waals
CXCL9 E293 7.28x27 TM7 polar (charge-assisted hydrogen bond)
CXCL9 E293 7.28x27 TM7 polar (charge-charge)
CXCL9 V296 7.31x30 TM7 polar (charge-assisted hydrogen bond)
CXCL9 D297 7.32x31 TM7 polar (charge-assisted hydrogen bond)
CXCL9 D297 7.32x31 TM7 polar (charge-charge)
CXCL9 K300 7.35x34 TM7 polar (charge-assisted hydrogen bond)
CXCL9 S304 7.39x38 TM7 Van der Waals
CXCL9 Y308 7.43x42 TM7 polar (charge-assisted hydrogen bond)
CXCL9 Y308 7.43x42 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 R T A L ICL1ECL1 Q W V F ECL1ICL2 A T Q L Y R R G P P ICL2ECL2 S A H H D E R L N A T H C Q Y N F ECL2ICL3 R G Q ICL3ECL3 A L A R ECL3N-term M V L E V S D H Q V L N D A E V A A L L E N F S S S Y D Y G E N E S D S C C T S P P C P N-termC-term G C P N Q R G L Q R Q P S S S R R D S S W S E T S E A S Y S G L C-term Q D F S L N F D R A F L P A L Y S L L F L L G L L G N G A V A A V L L S R S S T D T F L L H L A V A D T L L V L T L P L W A V D A A V G S G L C K V A G A L F N I N F Y A G A L L L A C I S F D R Y L N I V H A R V T L T C L A V W G L C L L F A L P D F I F L P Q V G R T A L R V L Q L V A G F L L P L L V M A Y C Y A H I L A V L L V S R R L R A M R L V V V V V V A F A L C W T P Y H L V V L V D I L M D L G N C G R E S R V D V A K S V T S G L G Y M H C C L N P L L Y A F V G V K M W M L F R E R L L L R
Helix box plot — Download: PNG | SVG G N G L L G L L F L L S Y L A P L F A R 1 L H L A V A D T L L V L T L P L W A V D 2 C A L L L A G A Y F N I N F L A G A V K 3 V T L T C L A V W G L C L L F A L P D 4 Y C Y A M V L L P L L F G A V L Q L V R L 5 V V V V V A F A L C W T P Y H L V V L V 6 L P N L C C H M Y G L G S T V S K A V 7

GPCRdb(A)
GPCRdb(A)
CXCR3
TM1
1x24 1.24x24 Q45
1x31 1.31x31 D52
TM2
2x60 2.60x60 W109
TM3
3x32 3.32x32 F131
3x33 3.33x33 N132
ECL2
45x50 45.50x50 C203
45x51 45.51x51 Q204
45x52 45.52x52 Y205
TM5
5x32 5.31x32 P208
5x33 5.32x33 Q209
5x36 5.35x36 R212
5x37 5.36x37 T213
5x40 5.39x40 R216
5x43 5.42x43 Q219
TM6
6x51 6.51x51 Y271
6x58 6.58x58 D278
6x62 6.62x62 D282
TM7
7x23 7.24x23 N289
7x24 7.25x24 C290
7x27 7.28x27 E293
7x30 7.31x30 V296
7x31 7.32x31 D297
7x34 7.35x34 K300
7x38 7.39x38 S304
7x42 7.43x42 Y308